Photobiological evaluation

Photochemotherapy is an efficient way to treat hyperproliferative diseases. Especially the so-called PUVA therapy (psoralen + UVA light) is very common in which the psoralen is irradiated with UVA light to give rise to a covalent adduct with the pyrimidine bases of DNA by means of a photoaddition reaction. There are several undesired side effects for the patients as a result of this therapy, so the synthesis and photobiological evaluation of novel benzosporalen derivatives was undertaken by the research team of L.D. Via. The key step in their synthetic sequence was the von Pechman reaction of 2-methoxyresorcinol with ethyl 2-oxocyclohexanecarboxylate. 

Dalla Via, L., Uriarte, E., Quezada, E., Dolmella, A., Ferlin Maria, G., Gia, O. Novel pyrone side tetracyclic psoralen derivatives synthesis and photobiological evaluation. J. Med. Chem. 2003, 46, 3800-3810. 

Photobiological hydrogen production is a theoretically more efficient process, but significant fundamental molecular research is needed to identify and improve the limiting factors in order to evaluate fully this approach for hydrogen production. 

Baertschi SW, Kinney HD, Snider BG. Issues in evaluating the in-use photostability of transdermal patches. Photostability 99, Joint Meeting with 27th Annual Meeting of the American Society for Photobiology, Washington, D.C., July 10-15, 1999. 

The photobiological properties of phthalocyanines will be reviewed in relation to their degree of hydrophobicity and two classes of photosensitizers will be defined, i.e. the hydrophilic Pc which are freely soluble in physiological solvents and the hydrophobic Pc, which require appropriate drug formulations, such as oil emulsion, liposomes or other colloidal systems. This review will focus on the in vivo evaluation of Pc. A recent review deals with more chemical aspects of this class of photosensitizers [8]. 

Kundu, D., Hazra, C., Chatteijee, A., Chaudhari, A., Mishra, S., 2014. Extracellular biosynthesis of zinc oxide nanoparticles using Rhodococcuspyridinivorans NT2 multifunctional textile finishing, biosafety evaluation and in vitro dmg delivery in colon carcinoma. Journal of Photochemistry and Photobiology, B Biology 140, 194—204. 

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