Phosphorylation, adenosine fatty acid oxidation

These are the energy producers within the cell. They generate energy in the form of Adenosine Tri-Phosphate (ATP). Generally, the more energy a cell needs, the more mitochondria it contains. Site for Kreb s Citric Acid Cycle Electron transport system and Oxidative Phosphorylation Fatty acid oxidation Amino acid catabolism Interconversion of carbon skeletons. 

ACC-2 produces malonyl CoA, which inhibits carnitine palmitoyl transferase I, thereby blocking fatty acid entry into the mitochondria. Muscle also contains malonyl CoA decarboxylase, which catalyzes the conversion of malonyl CoA to acetyl CoA and carbon dioxide. Thus, both the synthesis and degradation of malonyl CoA is carefully regulated in muscle cells to balance glucose and fatty acid oxidation. Both allosteric and covalent means of regulation are employed. Citrate activates ACC-2, and phosphorylation of ACC-2 by the adenosine monophosphate (AMP)-activated protein kinase inhibits ACC-2 activity. Phosphorylation of malonyl CoA decarboxylase by the AMP-activated protein kinase activates the enzyme, further enhancing fatty acid oxidation when energy levels are low. 

Phosphorus. Eighty-five percent of the phosphoms, the second most abundant element in the human body, is located in bones and teeth (24,35). Whereas there is constant exchange of calcium and phosphoms between bones and blood, there is very Httle turnover in teeth (25). The Ca P ratio in bones is constant at about 2 1. Every tissue and cell contains phosphoms, generally as a salt or ester of mono-, di-, or tribasic phosphoric acid, as phosphoHpids, or as phosphorylated sugars (24). Phosphoms is involved in a large number and wide variety of metaboHc functions. Examples are carbohydrate metaboHsm (36,37), adenosine triphosphate (ATP) from fatty acid metaboHsm (38), and oxidative phosphorylation (36,39). Common food sources rich in phosphoms are Hsted in Table 5 (see also Phosphorus compounds). 

Maintenance of adrenal cortex Promotes secretion of steroids, oxidative phosphorylation in adrenal cortex Mobilizes and increases oxidation of free fatty acid in adipose tissue Increases gluconeogenesis in liver increases cyclic adenosine monophosphate (AMP) in adrenal cortex Decreases urea formation in liver... 

Muscle glycogen phosphorylase, Uke its counterpart in the Uver, is activated by phosphorylation via phosphorylase kinase. Even in its dephosphorylated state, glycogen phosphorylase is activated aUosterically by adenosine monophosphate (AMP). AMP concentrations rise whenever ATP concentrations faU (Example 13.24), so if the combined effects of both fatty acid and glucose oxidation are unable to sustain normal ATP concentrations in contracting muscle, AMP concentrations rise quickly and stimulate glycogen phosphorylase. 

Minute spheres, rods, or filaments in the cytoplasm. Mitochondria are the sites of numerous biochemical reactions including amino acid and fatty acid catabolism, the oxidative reactions of the KreE)s cycle, respiratory electron transport, and oxidative phosphorylation. As a result of these reactions, mitochondria are the major producers of the high energy compound adenosine triphosphate (ATP) in aerobically grown cells. 

The principal function of the oxidation of carbohydrates and fatty acids is to make available to the cells the free energy released in the oxidation process, in a form physiologically usable for cellular energy processes, viz, ATP. This is accomplished by the process known as oxidative phosphorylation, whereby adenosine triphosphate (ATP) with three phosphate groups, two of which are held by high energy bonds, is formed from adenosine diphosphate (ADP) by the addition of phosphate. 

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