Phosphonous dichloride, -methyl

Methylphosphonic dichloride Phosphonic dichloride, methyl- (9) (676-97-1) Butyllithium Lithium, butyl- (8,9) (109-72-8)... 

The reaction of 2-deoxy-3,4,6-tri-0-methyl-2-methylamino-D-glucopyranose 149 with methyl(phenyl)phosphonic dichlorides (106a-b) or methylthiophosphonic dichloride in benzene in the presence of triethylamine afforded mixtures of four isomers of the corresponding 1,3,2 oxazaphospholidine-2-ones 150, 151 and... 

A rich family of 2-alkoxycarbonyl-l,3,2-oxazaphospholidine-2-oxides 179-181 was prepared from the reaction of camphor derived aminoalcohols 177 and 178 with either methoxycarbonyl phosphonic dichloride or ethyl dichlorophosphite followed by the reaction with methyl bromoacetate. The reaction with aminoalcohol 177a afforded the phosphorus epimers 179 and 180, in ratios from 1/1 to 12/1 depending on the iV-substituent which could be separated easily by column chromatography. The reaction with aminoalcohols 178a-c, however, gave a single epimer 181a-c in each case (Scheme 50) [81]. 

Weeks MH Acute vapor toxicity of phosphorus oxychloride, phosphorus trichloride and methyl phosphonic dichloride. Am Ind Hyg Arrowy 25 470-475, 1964... 

METHYL PHOSPHONIC DICHLORIDE see MOB399 METHYLPHOSPHONOFLUORIDIC ACID ISOPROPYL ESTER see IPXOOO METHYLPHOSPHONOFLUORIDIC ACID-1-METHYLETHYL ESTER see IPXOOO METHYLPHOSPHONOTHIOIC ACID-S-(2-(BIS(METHYLETHYL)AAaNO)ETHYL)o-ETHYL ESTER see EIGOOO... 

METHYL PHOSPHONOTHIOIC DICHLORIDE, pyrophoric liquid (DOT) see MOCOOO METHYI-PHOSPHONOUS DICHLORIDE see MOC250 METHYL PHTHALATE see DTR200 N-METHYL-2-PIPECOUC ACID, 2,6-DIMETHYLANILIDE see SBBOOO N-METHYI--2-PIPECOUC ACID, 2,6-XYLIDlDE see SBBOOO... 

ANTI)]-, ammonium, 26 24 C H2,Cl2PSis, Phosphonous dichloride, tris(trimcthylsilyl)methyl]-, 27 239 C, iH2iiSi), Methane, tris(trimethylsilyl)-, 27 238... 

PCIRuC.wH24. Ruthenium(II), chloro(T -hexamethylbenzene)hydrido(tri-phenylphosphine)-, 26 181 PCIiCiiHn, Phosphonous dichloride, (2,4,6-tri-tm-butylphenyl)-, 27 236 PCIjSiiCioHjT, Phosphonous dichloride, (tris(trimethylsilyl)methyl]-, 27 239 PCoC Hjo, Cobalt, (-ri -cyclopentadienyl)-(n -1, l -( 1,2-ethynediyl)bisbenzene]-(triphenylphosphine)-, 26 192 PCoCjiHm, Cobalt, (ii -cyclopentadienyl)-(2,3-dimethyl-1,4-diphenyl-l, 3-butadiene- 1,4-diy l)(tripheny Iphosphine)-, 26 195... 

Phosphonium, (carboxymelhyl)triphenyl-, bromide, ethyl ester, 70, 246 Phosphonous dichloride, phenyl- (644-97-3), 70, 273 Phthalimide, N-(3-bromopropyl)-, 70. 195 Piperidine, 2-methyl- (109-05-7), 70, 265 Pirkle Type 1-A column, 70, 64... 

Hydrogen-bond formation with phenol has been used in an i.r. study of v-(P=0) in the dioxaphospholans (98) to show that basicity depends on the nature of R and increases in the order OMeeight-membered 1,3,6,2-dioxazaphosphocines (99), which are currently of interest for comparison with the better known six-membered analogues, can be obtained from methyl-phosphonic dichloride and the appropriate 2,2 -iminobis(ethanol)." ... 

The reaction of chloromethylphosphonic dichloride with tetra-phosphorus decasulfide or with thiophosphoryl chloride are the only methods of preparation for this compound reported. The method is applicable more generally, and the syntheses of methyl-, trichloromethyl-, ethyl-, propyl-, cyclohexyl-, phenyl-, and -chlorophenylphosphonothioic dichloride from the corresponding phosphonic dichlorides have been reported. Phos-phinic chlorides of varying structures could also be converted to the corresponding thiono compounds by comparable procedures. The present method is preferable to the thiophosphoryl chloride procedure in that it does not require working under pressure. 

The procedure involves reaction in acetic anhydride, or in another solvent, followed by the addition of acetic anhydride to decompose the intermediate complex. The procedure has been extensively examined in relation to the 5-methyl- and 4,5-dimethyl-substituted compounds derived from ethenyl methyl and methyl isopropenyl ketones and with mesityl oxide which gives the 3,3,5-trimethyl-substituted compounds. Amongest the phosphorus reactants, the trichloride itself and methyl- " , ethyl- " " and phenyl- phosphonous dichlorides have been employed, as have ethyl and phenyP dichlorophosphites, ROPCI2. The use of 2-thienylphosphonous dichloride to give 137 is recorded as is that of the unsaturated ketone 138 to give 139. A more novel conversion is that of 140 into 141 in 25% yield with a similar conversion (15%) being observed for cholest-4-en-3-one. ... 

The nature of the solvent can sometimes influence the outcome of the reaction , but the latter is more significantly controlled by the nature of the alkene substrate. Whereas styrene retains unsaturation following phosphonylation, 3-arylprop-l-enes retain the HCl to form (2-chloro-3-arylpropyl)phosphonic dichlorides. (2-Propeny)trimethylsilane also reacts with retention of the HCl to give a phosphonic dichloride, which subsequently loses Me3SiCl to liberate (prop-2-enyl)phosphonic dichloride. Chloro(prop-2-enyl)-dimethyl- and dichloro(prop-2-enyl)methyl-silanes each yield an unsaturated phosphonic dichloride following the liberation of HCl, even at low temperatures the same study also showed some dependence of the success of the reaction on the quality of the PCI5 reagent. ... 

Cl2PSi3C,gH27, Phosphonous dichloride, [tris(trimethylsilyl)methyl]-, 27 239 Cl2P2PtC2gH24, Platinum, dichloro[l,2-ethanediylbis(diphenylphosphine)]-, 26 370... 

To a stirred solution of 105 g (0.396 mole) of [phenyl(tri-methylsilyl)methyl]phosphonous dichloride in 2-2.5 L of diethyl ether in a 4-L flask, 178 g (1.584 moles) of l,4-diazabicyclo[2.2.2]octane (DBO) is added. The mixture is stirred overnight at ambient temperature and then filtered. The solid is washed three times with 100-mL portions of pentane. The collected filtrates are concentrated to 1.5 L at ambient temperature under reduced pressure, and the base and its hydrochloride are separated by filtration. The solid is washed three times with 50-mL portions of pentane. This procedure (concentration and... 

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