Methylthiophosphonic dichloride

Treatment of (-)-ephedrine (42) with methylthiophosphonic dichloride afforded a mixture of the isomeric 2-methyl-l,3,2 oxazaphospholidine-2-thiones 120a,b, from which the pure isomers could be separated in approximately equal quantities by chromatography over silica (Scheme 34) [32],... 

The reaction of 2-deoxy-3,4,6-tri-0-methyl-2-methylamino-D-glucopyranose 149 with methyl(phenyl)phosphonic dichlorides (106a-b) or methylthiophosphonic dichloride in benzene in the presence of triethylamine afforded mixtures of four isomers of the corresponding 1,3,2 oxazaphospholidine-2-ones 150, 151 and... 

Methylphosphonous dichloride, MePClj, bp=81°C, oxidises spontaneously in air and it can be oxidised by various compounds including O2, N2O and SO2CI, to methylphosphonic dichloride, MePOa2 (6.184,6.188). Chlorine converts it into methyl tetrachlorophosphorane, MePC (6.494) and with PSQj, methylthiophosphonic dichloride, MePSCl2, is obtained (9.427). 

The 0,N,P-heterocycles (56) and their 1,2-trans-isomers have been synthesized from 2-N-methyl-3,4,6-tri- -methyl-D-glucopyranose and methylthiophosphonic dichloride (MePSCl2) and their cleavage to... 

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