Phospholipase C gamma

Deans JP, Sehieven GL, Shu GL et al. Association of tyrosine and serine kinases with the B-cell sur-faee antigen CD20 induetion via CD20 of tyrosine phosphorylation and activation of phospholipase C-gamma 1 and PLC phospholipase C-gamma 2. JImmunol 1993 151 4494 504. 

L. Ronnstrand, S. Mori, A. K. Amdsson, A. Eriksson, C. Wemstedt, U. Heilman, et al. Identification of two C-terminal autophosphorylation sites in the PDGF beta-receptor involvement in the interaction with phospholipase C-gamma. EMBOJ, 11 (11), 3911-3919, 1992. 

A. Kashishian and J. A. Cooper. Phosphorylation sites at the C-terminus of the platelet-derived growth factor receptor bind phospholipase C gamma 1. Mol Biol Cell, 41, 49-57, 1993. 

M. Valius and A. Kazlauskas. Phospholipase C-gamma 1 and phosphatidylinositol 3 kinase are the downstream mediators of the PDGF receptor s mitogenic signal. Cell, 73 (2), 321-334, 1993. 

D. Rotin, A. M. Honegger, B. L. Maigolis, A. Ullrich, and J. Schlessinger. Presence of SH2 domains of phospholipase C gamma 1 enhances substrate phosphor tion by increasing the affinity toward the epidermal growth factor receptor. J Bid Chem, 267 (14), 9678-9683, 1992. 

Gusovsky, E, Lueders, J.E., Kohn, E.C., and Eelder, C.C. 1993. Muscarinic receptor-mediated tyrosine phosphorylation of phospholipase C-gamma. Chem 268, 7768-7772. 

Blake RA, SCHIEVEN GL, Watson SP. Collagen stimulates tyrosine phosphorylation of phospholipase C-gamma 2 but not phospholipase C-gamma 1 in human platdets FEBS Lett 353 212-216,19. ... 

KEELY P-J, PARISE L-V. The alpha-2-beta-1 integrin is a necessary co-receptor for collagoi-induced activation of Syk and the subsequent i sphorylation of phospholipase C-gamma-2 in platelds. JBiol Chem 271 26668-26676,1996. 

Gurd JW, Bissoon N. 1997. The N-methyl-D-aspartate receptor subunits NR2A and NR2B bind to the SH2 domains of phospholipase C-gamma. J. Neurochem. 69 623-30... 

Inhibitors of serine/threonine phosphatases, such as okadaic acid or microcystin, can be used to investigate the effects of serine/threonine phosphorylation on kinase targeting. Tyrosine phosphatase inhibitors can be used to investigate the effect of tyrosine phosphorylation on kinase targeting in a specific cell type. For example, orthovanadate has been shown to induce translocation of the immunoreactivity of phospholipase C gamma from the cytosolic to the membrane fraction of mast cells (Atkinson et al, 1993). Conversely, in permeabilized preparations, the phosphatases themselves, if known, can be added to inhibit the putative pathway. 

Zhang W, Trible RP, Zhu M, Liu SK, McGlade CJ, Samelson LE 2000 Association of Grb2, Gads, and phospholipase C-gamma 1 with phosphorylated LAT tyrosine residues. Effect of LAT tyrosine mutations on T cell antigen receptor-mediated signaling. J Biol Chem 275 23355-23361... 

Landgren E, Schiller P, Cao Y, Claesson-Welsh L. Placenta growth factor stimulates MAP kinase and mitogenicity but not phospholipase C-gamma and migration of endothelial cells expressing Fit 1. Oncogene 1998 16 359-367. 

Pascal, S.M., Singer, A.U., Gish, G., Yamazaki, T, Shoelson, S.E., Pawson, T, Kay, L.E., and Forman, K.J., Nuclear magnetic resonance structure of an SH2 domain of phospholipase C-gamma 1 complexed with a high affinity binding peptide. Cell, 77,461,1994. 

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