Phosphates biology

Chemistry of Thioesters and Acyl Phosphates Biological Carboxylic Acid Derivatives 817... 

NH2-aminopropyl Weak anion/polar Phosphates Biological fluids ... 

In plant tissues two major forms of polyprenols are found, e.g. free alcohols and esters with fatty acids. In some species one form is highly dominating. Similarly in animal tissues dolichols and dolichyl esters were described, accompanied by usually small amounts of dolichyl phosphate. Biological role of this latter compound is well established. Dolichyl phosphate is involved as cofactor in biosynthesis of glycoproteins and GPI-anchored proteins [3]. Biological role of free alcohol and its acyl ester has not been defined yet. As the components of biological membranes these compounds modulate membrane properties. Dolichol increases fluidity and permeability and decreases the stability of model membranes [4]. Experiments with polyprenols point to the same direction polyprenols and polyprenyl phosphates increases the fluidity and permeability of model membranes [5], Both polyprenols and dolichols could also serve as a reserve isoprenoid pool utilized by corresponding kinases. 

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