Phosphate, biological accumulation

Initially, it was thought that FGF23 was a direct substrate for PHEX, but this no longer appears to be the case. In either disease, intact and biologically active FGF23 accumulates, leading to phosphate wasting in the urine and hypophosphatemia. 

T. Mino (2000). Microbial selection of polyphosphate-accumulating bacteria in activated sludge wastewater treatment process for enhanced biological phosphate removal, Biochemistry (Moscow), 65, 541-549. 

Raboy, V, 1997, Accumulation and storage of phosphate and minerals. In Larkins, B.A., Vasil, I.K. (eds.), Cellular and Molecular Biology of Plant Seed Development. Kluwer Academic Publishers, Dordrecht Netherlands, pp. 441-477. 

A further effect of lithium on receptor-activated cells is accumulation of diacylglycerol, which may increase or prolong the activation of protein kinase C (107). It should be noted that diacylglycerol and D-inositol l,4,5-tris(phosphate) are separate branches of two parallel signaling systems that initially are coherent. Metabolic interference by lithium to desynchronize these systems may itself be a signaling system. This is analogous with beat phenomena seen in the desynchronization of biological cycles by rapid movement between time zones. 

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