Phosphate intravenous

Intravenous formulations contain either sodium 4 mEq/mL or potassium 4.4 mEq/mL with 3 mmol/mL phosphate ° Symptomatic and severe hypophosphatemia (<1 mg/dL)... 

Administer hydrocortisone sodium phosphate or hydrocortisone sodium succinate, 100 mg intravenously every 6 to 8 hours for 24 hours. 

Electrolyte disturbances that develop in patients with tumor lysis syndrome should be managed aggressively to avoid renal failure from hyperphosphatemia and hypocalcemia and cardiac signs from hyperkalemia. One exception pertains to the use of intravenous calcium for hypocalcemia. Adding calcium may cause further calcium phosphate precipitation in the presence of hyperphosphatemia and should be used cautiously. 

Gatz. 1992a. Intravenous and dermal absorption, distribution, and excretion of 14C-tributyl phosphate in Yucatan minipigs Part I. MRI Project No. 9526-F(02). 

Baker et al. [137] reported that Rhesus monkeys were administered primaquine (6-10.5 mg as the phosphate/kg intravenously) and plasma samples were analyzed by high performance liquid chromatography for the presence of the unchanged drug and the major metabolite, 8-[3-carboxy-l-methylpropylamino)-6-methoxyquinoline. Primaquine had an unusually high affinity for tissue compartments, which produced a rapid initial drop in plasma concentration. Within 15 min, the plasma concentration of the metabolite far exceeded that of primaquine. Thirty-five to eighty-three percent of the primaquine dose was converted to the major metabolite. This metabolite possessed much lower affinity for the tissues compartments than the drug itself. 

IVPB, intravenous piggyback K, potassium Na, sodium P04, phosphate. Monitor serum K closely. 

Calcium and Phosphate Needs of Preterm Infants Requiring Prolonged Intravenous Feeding... 

Our simple approach to determining the optimal Ca/P ratio for intravenous feeding solutions was to simply alter the ratio of calcium to phosphate in these solutions and measure the only external loss of calcium and phosphate which was in the urine. We initially assumed that the difference between the intake and urinary loss of calcium and phosphate would measure the retention of these elements. The results of seven balance studies at varying Ca/P ratios are shown in Figure 5. 

Figure 5. The areas above the measured calcium and measured phosphate retention curves represent the percent of the intravenously administered calcium and phosphate that was lost in the urine. The combined percent losses (Ca + P) are minimized at the intercept of the curves. The dotted line represents an assumed endogenous fecal loss of 20% of the infused calcium added to the measured urinary calcium losses. The Ca/P ratio that minimizes the percent calcium and phosphate losses is then approximately 3.0. (Reproduced with permission from Ref. 4. Copyright 1983 American Society for Parenteral and Enteral Nutrition.)...

One of the reasons for suspecting that variations in parathyroid functioning are great is the fact that experimental animals have striking individual sensitivity to administered hormone. This fact has been noted particularly in dogs which have been used for assay animals. Also, in one study involving humans it was found that four normal individuals had their phosphate clearance increased 60 per cent, 190 per cent, 150 per cent, and 110 per cent, respectively, when 200 units of the hormone was administered intravenously, while two individu-... 

T. L. Morton, E. A. Murrill, J. M. Cannon, J. L. Skaptason, E. C. Bisinger, V. Reddy, R. N. Gatz, Absorption, Distribution, Metabolism and Excretion of 14C-Tributyl Phosphate in Sprague-Dawley Rats Following Dermal, Oral and Intravenous Administration , in Proceedings of the Fifth North American ISSX Meeting , Tucson, Arizona, USA, October 17-21, 1993, p. 196. 

Formulation Aranesp is formulated as a sterile, colorless, preservative-free protein solution for intravenous (IV) or subcutaneous (SC) administration. There are two formulations the polysorbate solution includes excipients such as polysorbate 80, sodium phosphate monobasic monohydrate, sodium phosphate dibasic anhydrous, and sodium chloride in water-for-injection while the albumin solution contains albumin, sodium phosphate monobasic monohydrate, sodium phosphate dibasic anhydrous, and sodium chloride in water-for-injection. The pH for both formulations is 6.2 + 0.2. 

Oberbauer et al. reported inhibition of a sodium/phosphate (Na/Pi-2) co-transporter by phosphorothioated AS-ODN. A single intravenous injection of the AS-ODN inhibited both the mRNA and the protein for the Na/Pi-2 co-transporter, and conseqnently snppressed In-minal uptake of phosphate by the proximal tubules [130],... 

Intravenous administration of 4—lOmg/kg produced bradycardia and an initial transient hypertensive effect in the anesthetized dog. Toxicity is thought to occur from the decomposition of decaborane to a stable intermediate that in turn inhibits intracellular pyri-doxal phosphate-requiring enzymes. ... 

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