Pheromone binding OBPs

Insect OBPs are secretory proteins whose only posttranslational modification is the formation of three disulfide bridges [39,45] from six cysteine residues. That six cysteine residues are well conserved in OBPs from species of the same order is a hallmark of these proteins. The disulfide links of OBPs in a few species have been determined by analytical methods, first in the OBPs from B. mori [45,46]. As part of our attempt to get better insight into the structural biology of pheromone-binding proteins, we have determined the disulfide linkages... 

Unfortunately, the term OBP has been rather imprecisely used in the literature. It sometimes refers to the olfactory function played by proteins, such as the pheromone-binding protein from BmorPBP. However, quite often OBP... 

The first identified insect OBP was the pheromone binding protein (PBP) of the silk moth A. polyphemus (Vogt and Riddiford, 1981). This 14 kDa protein appeared to be specific to the male antenna, was perhaps the most abundant soluble protein in the antenna, was located in the aqueous extracellular fluid that bathed the pheromone sensitive neurons, and could bind sex pheromone. The concentration of ApolPBP within the sensillum fluid was estimated to be about... 

In 1981, the pheromone binding protein (PBP) and sensilla esterase (SE) of Antheraea polyphemus were identified [44] and in 1985 a new model for pheromone detection was proposed, in opposition to the previous model. In this model, PBPs transported pheromone to receptor proteins (replacing pore-tubules in this role) and SE rapidly inactivated pheromone by enzymatic degradation [45]. PBPs have become established as only a subclass of a much larger family of insect OBPs that are represented at least throughout the neopterous insects, from cockroach to honeybee. 

STRUCTURE AND FUNCTION OF INSECT ODORANT AND PHEROMONE-BINDING PROTEINS (OBPs AND PBPs) AND CHEMOSENSORY-SPECIFIC PROTEINS (CSPs)... 

PHEROMONE-BINDING PROTEINS AND ODORANT-BINDING PROTEINS (PBPS AND OBPS)... 

Proteins that bind odorants or pheromones in insects belong to the OBP family. This family can be divided into three major classes pheromone-binding... 

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