Phenyl butyrate

The 2-phenyl-2-ethyl-pentane-1,5-diacid-mononitrile-(1) of melting point 72° to 76°C, used as starting material in this process, can be produced for example from o-phenyl-butyric acid nitrile by condensation with acrylic acid methyl ester and subsequent hydrolysis of the thus-obtained 2-phenyl-2-ethyl-pentane-1,5-diacid-monomethyl ester-mononltrile-(l) of boiling point 176° to 185°C under 12 mm pressure. 

Chemical Name Prednisolone 21 -[4 -[p-bis(2-chloroethyl)amino] phenyl] butyrate Common Name Prednisolone chlorambucil ester... 

The reaction mixture was then kept at room temperature for 1 hour and thereafter poured into a mixture of 5.0N HCI and crushed ice. The benzene solution was immediately washed with water, with cold 1. ON NaHCOsand finally with cold water. After drying over anhydrous sodium sulfate, the benzene was removed in vacuo. The residue is the p-[N-bis(/3-chloroethyD-amino] phenyl butyric anhydride which could be used without any further purification. 

To a solution of 42.0 g of p-[N-bis(/3-chloroethyl)amino] phenyl butyric anhydride in 500 ml dry pyridine was added 24.4 g of prednisolone. The reaction mixture was kept at room temperature for 24 hours under anhydrous condition. It was then poured into a mixture of concentrated HCI and crushed ice and extracted with ether-ethyl acetate (1 1). 

Bis(/3Estramustine phosphate p-[N-bis(/3phenyl-butyric acid Prednimustine... 

The deep red solution is cooled in an ice bath and neutralized by the addition, with shaking, of an ice-cold solution of 15 cc. of concentrated sulfuric acid in 200 cc. of water. The ether layer is separated, washed with water, and dried over sodium sulfate. The ether is removed by dropping the solution from a separatory funnel the stem of which extends to the bottom of an evacuated Claisen flask heated on the steam bath. The residue is a pale yellow oil consisting of a mixture of ethyl a-ethoxalyl-y-phenyl-butyrate and unchanged ethyl oxalate (Note 5). 

Cyano-2-phenyl-butyric acid ethyl ester (VI)... 

Fig. 10.—Benzoyl peroxide-initiated polymerization of vinyl-i-j3-phenyl-butyrate in dioxane at 60°C plotted as a first-order reaction. [M]o and [M ] represent concentrations of monomer initially and at time t, respectively. In experiments 1, 2, and 3, respectively, [M]o = 2.4, 7.28, and 5.97 g. of monomer per 100 cc. of dioxane. (Results of Marvel, Dec, and Cooke obtained po-larimetrically.)...

Simoni S, S Klinke, C Zipper, W Angst, H-P E Kohler (1996) Enantioselective metabolism of chiral 3-phenyl-butyric acid, an intermediate of linear alkylbenzene degradation, by Rhodococcus rhodochrous. Appl... 

FIGURE 2.24 Calculated signal profiles for the single components (thin lines the first peak represents 2-phenyl butyric acid and the second peak represents benzophenone) and the mixture (thick line). 

The mesogenic units with methylenic spacers were prepared by reacting the sodium salt of either 4-methoxy-4 -hydroxybiphenyl or 4-phenylphenol with a bromoester in DMF at 82° C for at least 4 hours in the presence of tetrabutylammonium hydrogen sulfate (TBAH) as phase transfer catalyst. In this way, ethyl 4-(4-oxybi-phenyl)butyrate, ethyl 4-(4-methoxy-4 -oxybiphenyl)butyrate, ethyl 4-(4-oxybiphenyl)valerate, ethyl 4-(4-methoxy-4 -oxybiphenyl)-valerate, n-propyl 4-(4-oxybiphenyl)undecanoate and n-propyl 4-(4-methoxy-4 -oxybiphenyl)undecanoate were obtained. These esters were hydrolyzed with base and acidified to obtain the carboxylic acids. The corresponding potassium carboxylates were obtained by reaction with approximately stoichiometric amounts of potassium hydroxide. Experimental details of these syntheses were described elsewhere (27). 

Schmidt, E., Ghisalba, O., Gygax, D. and Sedelmeier, G. (1992) Optimization of a process for the enzymatic production of fA )-2-hyroxy-4-phenyl butyric acid - an intermediate for inhibitors of angiotensin converting enzymes. Journal of Biotechnology, 24, 315-327. 

The Y phenyl butyric acid is cyclised to a-tetralone by converting it into the acid chloride with thionyl chloride or phosphorus pentachloride and then an intramolecular Friedel and Crafts reaction is carried out ... 

T. C. Tranter (36) has studied the binary copolymers based on hexamethylene diamine and -phenylene dipropionic, 3-(/>-carboxy-methyl)phenyl-butyric, 2-(/>-carbomethoxy)phenylpropionic, hydro-quinone diacetic, terephthalic, adipic, or sebacic acids. In spite of the fact that only the copolymers of hexamethylene diamine with/>-phenylene dipropionic and with 2-(/>-carbomethoxy)phenylpropionic acids show a linear softening point composition curve, Tranter claims for isomorphism in the copolymers of all the systems. In fact, their X-ray examination shows that they behave in the same basic manner, the second component dissolving in the lattice of the first until a certain critical concentration is reached, where the lattice structure changes quite abruptly to that of the second component. 

Leone-Bay, A., et al. 1996. 4-[4-[(2-Hydroxybenzoyl)amino]phenyl]butyric acid as a novel oral delivery agent for recombinant human growth hormone. J Med Chem 39 2571. 

Methyl )3-benzoyl propionate Methyl y-phenyl butyrate 45°, 41b... 

The residue is prednisolone 21-[4 -[p-bis(p-chloroethyl)amino]phenyl]butyrate which after crystallization from methanol/water had a melting point of 163°C to 164°C. 

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