2- -3-phenoxypropyl phenyl

Inhibitors for proteases plasmepsin I and II of the malaria parasite Plasmodium falciparum, with a good plasmepsin/human protease cathepsin D selectivity, have been identified via library construction involving rapid microwave-accelerated Suzuki reactions [57]. The phenyl ring of the biphenyl unit in the lead compound M-((lS)-l- [((lS,2S)-3- [(lS)-2-amino-l-(4-phenyl-benzyl)-2-oxoethyl]amino -2-hydroxy-l-phenoxypropyl)amino]carbonyl -2-methylpropyl)pyridine-2-carboxamide has been altered by performing Suzuki reactions on N-((lS)-l- [((lS,2S)-3- [(lS)-2-amino-l-(4-bromobenzyl)-2-oxoethyl]amino -2-hydroxy-l-phenoxypropyl)amino]carbonyl -2-methyl-propyl)pyridine-2-carboxamide (Scheme 37). In particular, a 2-benzofuryl moiety proved to be interesting since a Ki value of 13 nM for plasmepsin I and... 

Thymidine and 2 -deoxyadenosine react with phenyl glycidyl ether in vitro. The main adducts are A-3-(2-hydroxy-3-phenoxypropyl)thymidine and Wl-(2-hydroxy-3-phenoxypropyl)-2 -deoxyadenosine, respectively. With longer reaction times, a small amount of dialkylated 2 -deoxyadenosine was also formed (Van den Eeckhout et al., 1990). 

Halo ethers are prepared by adding an alcoholic solution of the sodium alkoxide to the polymethylene halide, X(CHj) X, in anhydrous ether or benzene, as illustrated by the preparation of l-bromo-6-methoxyhexane (47%). In a somewhat different manner, an aromatic halo ether such as y-phenoxypropyl bromide is synthesized by the action of phenol and the dihalide in the presence of hot aqueous sodium hydroxide (85%). The syntheses of o- and p-chlorophenyl phenyl ethers have been successfully accomplished by the Ullmann procedure (40-55%), whereas chlorination of diphenyl ether yields an inseparable mixture of isomers. ... 

Phenoxypropyl alcohol. See Propylene glycol phenyl ether... 

N-Acetylation. A soln. of cupric acetate monohydrate in ethanol added to a soln. of l-(3-phenoxypropyl)-3-phen-yl-2-thiourea in the same solvent, and refluxed 7 hrs. l-(3-phenoxypro-pyl)-3-phenyl-3-acetylurea. Y 83%. 

Acetone, methyl ethyl ketone, methyl propyl ketone, methyl isobutyl ketone, methyl -amyl ketone, 2-heptanone, 2-octanone, methyl isohexyl ketone, 4-methyl-2-heptanone, methyl cyclohexyl ketone, methyl- -phenoxypropyl ketone, benzylacetone, benzohydrylacetone, 2--phenyl ethyl methyl ketone... 

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