Phenothiazines Calcium-channel blockers

Medications (analgesics, anticholinergerics, calcium channel blockers, clonidine, diuretics, phenothiazines, tricyclic antidepressants, iron supplements, calcium- and aluminum-containing antacids)... 

Drugs that may affect repaglinide include CYP 450 inhibitors (eg, clarithromycin, erythromycin, ketoconazole, miconazole), CYP 450 inducers (eg, barbiturates, carbamazepine, rifampin), beta blockers, calcium channel blockers, chloramphenicol, corticosteroids, coumarins, estrogens, gemfibrozil, isoniazid, itraconazole, levonorgestrel and ethinyl estradiol, MAOIs, nicotinic acid, NSAIDs, oral contraceptives, phenothiazines, phenytoin, probenecid, salicylates, simvastatin, sulfonamides, sympathomimetics, thiazides and other diuretics, and thyroid products. 

Drugs that may interact with nitrates include alcohol, alteplase, aspirin, beta-blockers, calcium channel blockers, dihydroergotamine, heparin, nondepolarizing muscle relaxants, phenothiazines, phosphodiesterase inhibitors (eg, sildenafil, tadalafil, vardenafil), and vasodilators. 

Thiazides and other diuretics Corticosteroids Phenothiazines Thyroid products Estrogens Oral contraceptives Phenytoin Nicotinic acid Sympathomimetics Calcium channel blockers Isoniazid Miconazole... 

Drugs that tend to produce hyperglycemia (thiazide and other diuretics, corticosteroids, phenothiazines, thyroid products, estrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics, calcium channel blockers, isoniazid)... 

CALCIUM CHANNEL BLOCKERS ANTIPSYCHOTICS t antihypertensive effect Dose-related 1 BP (due to vasodilatation) is a side-effect of most antipsychotics, particularly phenothiazines Monitor BP especially during initiation of treatment. Warn patients to report symptoms of hypotension (light-headedness, dizziness on standing, etc.)... 

Assess medical and drug history, report if taking phenothiazines, digoxin, calcium channel blockers, or other antihypertensives. 

B. Toxicodynamics Toxicodynamics is a term used to denote the injurious effects of toxins, ie, their pharmacodynamics. A knowledge of toxicodynamics can be useful in the diagnosis and management of poisoning. For example, hypertension and tachycardia are typically seen in overdoses with amphetamines, cocaine, and antimuscarinic drugs. Hypotension with bradycardia occurs with overdoses of calcium channel blockers, beta-blockers, and sedative-hypnotics. Hypotension with tachycardia occurs with tricyclic antidepressants, phenothiazines, and theophylline. Hyperthermia is most frequently a result of overdose of drugs with antimuscarinic actions, the salicylates, or sympathomimetics. Hypothermia is more likely to occur with toxic doses of ethanol and other CNS depressants. Increased respiratory rate is often a feature of... 

An isolated report describes cardiopulmonary arrest in a patient taking mefloquine with propranolol. The WHO have issued a warning about the concurrent use of mefloquine with an-tiarrhythmics, beta blockers, calcium-channel blockers, antihistamines, phenothiazines, and some related antimalarials. For mention that halofantrine should not be used with or after mefloquine, because of a clinically significant lengthening of the QT interval, see Halofantrine + Miscellaneous , p.229. 

A patient taking chlorpromazine who was given nifedipine [dosage not stated] for 2 days before snidery, developed marked hypotension during surgery, which was eventually controlled with noradrenaline (norepinephrine). Other phenothiazines and calcium-channel blockers may interact similarly, see Antihypertensives + Other drugs that affect blood pressure , p.880. 

Medications P-blockers, calcium channel blockers, antiarrhythmics, chemotherapy, lithium, phenothiazines, cimetidine, tricyclic antidepressants... 

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