Pharmacology basic concepts

A basic concept in receptor pharmacology is the idea of orthosteric and allosteric interaction. Orthosteric interaction occurs when two molecules compete for a single binding domain on the receptor. With allosteric interactions two molecules each have their own binding domain on the receptor and the two interact through effects on the protein (conformational change). Tims, with orthosteric interactions only one molecule may occupy the receptor at any one instant whereas with allosteric interactions both molecules can bind to the receptor at the same time. There are implications for... 

Despite this unfortunate disparity between molecular neurobiology and behavioural pharmacology, it is essential that the neuropharmacologist and biological psychiatrist are fully conversant with the basic concepts of the subject in order to appreciate both its success and limitations. 

Merck Manual of Diagnosis and Therapy. Sec. 22 Clinical Pharmacology. URL http //www.merck.com/mrkshared/ mmanual/section22/sec22.jsp. [25 October 2005]. Free Web version of the Merck Manual. Clinical Pharmacology section provides an overview of the basic concepts of pharmacokinetics, pharmacodynamics, and toxicity. 

This chapter introduces the basic concepts of carcinogenesis, tumor growth, and cancer treatment, provides general information on the pharmacology and clinical use of the antineoplastic agents, and presents an overview of supportive care issues in the oncology patient. 

B22. Brodie, B. B., Basic principles in development of methods for drug assay. In Concepts in Biochemical Pharmacology (B. B. Brodie and J. R. Gillette, eds.). Handbook of Experimental Pharmacology, Vol. 28, Part 2, pp. 1-8. Springer-Verlag, Berlin and New York, 1971. 

These data are required by regulatory agencies and vital for physicians. Pharmaceutical scientists also use this information as a basis for the discovery and development of new drugs. A clear understanding of basic pharmacology and the concepts unique to characterization and evaluation of therapeutic proteins and biologies, as opposed to small molecules, is essential for optimal use of these agents. 

The Law of Initial Value is a fascinating, and largely under-appreciated, concept worthy of additional discussions that are beyond the scope of this book. Indeed, the various basics of neuroscience and pharmacology just summarized barely scratch the surface of all that has been learned over the years about the... 

As in previous editions, basic pharmacology concepts are addressed in the first section (Chapters 1 through 4), with subsequent chapters dealing with... 

On the other hand, pharmacological wake promotion is a new concept brought about by modafinil. Use of modafinil for medical conditions other than narcolepsy has begun to receive the attention of both basic and applied researchers and physicians caring for these patients. Moreover, modafinil consumption is envisioned by some as logical for some critical occupational situa-... 

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