Pharmacologic-interaction concept

However, in the p-i concept there is a pharmacological interaction (low affinity) between the drug and the peptide-MHC molecule on the surface of the APC, with weak binding but sufficient to activate T cells, which have receptors for the MHC. 

PIchler WJ, Beeler A, Keller M, Lerch M, Posadas S, Schmid D, Spanou Z, Zawodniak A, Gerber B Pharmacological Interaction of drugs with Immune receptors the p-l concept. Allergol Int 2006 55 17-25. 

Pichler WJ. Pharmacological interaction of drugs with autigeu-specific immuue receptors the p-i concept. Curr Opin Allergy Clin Immunol 2002 2 301-305. 

Pichler WJ (2002) Pharmacological interaction of drugs with antigen-specific immune receptors the p-i concept. Curr Opin Allerg Clin Immunol 2 301-305 Pichler WJ (2005) Direct T-cell stimulations by drugs-bypassing the irmate immune system. Toxicology 209 95-100... 

Keywords Drug hypersensitivity T cells p-i concept (pharmacological interaction of drugs with immune receptors) Mechanism Exanthema... 

A basic concept in receptor pharmacology is the idea of orthosteric and allosteric interaction. Orthosteric interaction occurs when two molecules compete for a single binding domain on the receptor. With allosteric interactions two molecules each have their own binding domain on the receptor and the two interact through effects on the protein (conformational change). Tims, with orthosteric interactions only one molecule may occupy the receptor at any one instant whereas with allosteric interactions both molecules can bind to the receptor at the same time. There are implications for... 

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