Pharmacological interaction hypothesis

A case report was published on a patient who suffered nevirapine-induced hepatitis and had peripheral mononuclear cells that were activated by nevirapine (Drummond et al. 2006). In addition, a poster by Keane et al. (2007) reported patients which a history of nevirapine hypersensitivity reactions whose peripheral mononuclear cells responded to nevirapine with the production of IFN-y. This is consistent with the pharmacological interaction (p-i) hypothesis (Pichler... 

These results further support the hypothesis that potent synthetic agonists of octopamine-sensitive adenylate cyclase should be useful as selective pesticides. The results also suggest that if compounds could be developed which were potent against the octopamine-sensitive adenylate cyclases present in a wide variety of insect species, they should, similarly, have a wide spectrum of insecticidal activity. However, in order to develop such compounds, much more needs to be known about a) the molecular pharmacology of octopamine receptors and b) the interspecies differences which seem to exist in the characteristics of such receptors. In other words, we need to know if there exist single or multiple octopamine receptor subtypes which interact with adenylate cyclase, and if multiple, how these subtypes vary among different species. 

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