Pharmacogenetics methodology

Studies such as these highlight the usefulness of pharmacogenetics to prescreen patients for therapy/dose selection. There are many methodologies available for pharmacogenetics studies. Some of the criteria specific to cancer pharmacogenetics are highlighted in this chapter. 

In short, differences in drug response between human populations drew first attention 4 to 5 decades ago. However, because of the initial methodological shortcomings, the science of interethnic pharmacogenetics is in a strict sense only about 20 years old (10). 

Tyhring G, Bertilsson L. A methodological investigation on the estimation of the (S)-mephenytoin hydroxylation phenotype using the urinary S/R ratio. Pharmacogenetics 1992 2 241-243. 

These methodological differences account, at least in part, for the lack of replication observed across pharmacogenetic studies of antipsychotic response. Despite the challenges of conducting genetic studies in this area, a number of variants have shown consistent association with antipsychotic metabolism and response (Table 3). 

Zhang JP, Malhotra AK (2013) Pharmacogenetics of antipsychotics recent progress and methodological issues. Expert Opin Drug Metab Toxicol 9 183-191... 

Carleton B (2010) Demonstrating utility of pharmacogenetics in pediatric population methodological considerations. Clin Pharmacol Ther 88 757-759... 

As described previously, pharmacogenetics began with the study of single gene differences between individuals but developed into a broad science. Methodological advances expanded the science further into pharmacogenomics one... 

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