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Pharmaceuticals lignans

The pharmaceutically very interesting dibenzocyclooctadiene lignans, such as steganacin, steganone and schizandrin8-10, constitute ideal synthetic substrates for this method since they have the required oxygenation pattern. [Pg.573]

Lignans are a well-known class of widespread natural phenolic compounds that exhibit great structural and biological diversity and are commonly found in vascular plants from various families [1]. They are present at different levels of abundance in all plant parts, including roots, rhizomes, hardwood, bark, stems, leaves, flowers, fruits and seeds [2]. Lignans are of considerable pharmacological and clinical interest and are used in the treatment of cancer and other diseases [3]. The extensive pharmaceutical use of lignans is due to their antitumor, antiviral and hepatoprotective properties as well as many other beneficial activities. [Pg.104]

A limited clinical trial of podophyllotoxin and a co-occurring lignan, a-peltatin, was carried out in the early 1950s, but although some short-lived responses were observed, the general toxicity of the two compounds precluded further studies. At about the same time (1954), the Swiss pharmaceutical company Sandoz embarked on a programme of chemistry directed towards the... [Pg.180]

A Three Viscum samples (3-5) collected from different trees show syringin (T4) at R, — 0.45, and a variation of blue-violet and yellow zones due to other lignans and various phenol carboxylic acids. The pharmaceutical preparation 6 has an additional prominent blue zone above the syringin test. [Pg.270]

Many plant phenolics are of pharmaceutical interest. Flavonoids, lignans, flavolignans, coumarins, phenyl pro-panoids, and other phenolic compounds show a wide variety of biological and pharmacological activities, such as anti-oxidant, anti-hepatotoxic, spasmolytic, cytotoxic, anti-fungal, and anti-bacterial. Some flavonoids improve capillary resistance while isoflavonoids found in soy and other legumes have estrogenic activity. [Pg.1548]

Lignans are C-18 natural compounds formed essentially by the union of two molecules of phenylpropene (C-6, C-3) formed from cinnamate derivatives. Lignans are optically active compounds and the union takes place between the middle carbons of the monomers side chains. Important pharmaceutical examples are the lignans of Podophyllum... [Pg.1549]

The lignans are becoming increasingly important for their physiological and pharmaceutical properties. [Pg.148]

Tanaka, N., T. Kido, T. Murakami, Y. Saiki, and C.-M. Chen Novel Lignans from the Blechnaceae. 107th Annual Meeting of the Pharmaceutical Society of Japan, Kyoto, Apr. 1987, Abstracts of Papers, p. 351. [Pg.306]


See other pages where Pharmaceuticals lignans is mentioned: [Pg.13]    [Pg.187]    [Pg.592]    [Pg.213]    [Pg.1576]    [Pg.326]    [Pg.41]    [Pg.542]    [Pg.171]    [Pg.779]    [Pg.317]    [Pg.334]    [Pg.37]    [Pg.1053]    [Pg.554]    [Pg.120]    [Pg.4]   
See also in sourсe #XX -- [ Pg.181 ]




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Lignan

Lignans

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