Pharmaceutically active compounds rejection

Kimura K, Amy G, Drewes JE, Heberer T, Kim T-U, Watanabe Y (2003) Rejection of organic micropollutants (disinfection by-products, endocrine dismpting compounds, and pharmaceutically active compounds) by NF/RO membranes. J Membr Sci 227 113-121... 

Kimura K, Toshima S, Amy G, Watanabe Y (2004) Rejection of neutral endocrine disrupting compounds (EDCs) and pharmaceutical active compounds (PhACs) by RO membranes. J Membr Sci 245 71... 

Xie, M., Price, WE. Nghiem, L.D. (2012b) Rejection of pharmaceutically active compounds by forward osmosis role of solution pH and membrane orientation. Separation and Purification Technology, 93, 107-114. 

Furthermore, it may be possible to view the pharmaceutical literature as a vast library to be screened for organocatalytic, not just medidnal, activity. Many compounds that are now off-patent, or were rejected in the early stages of clinical trials, could be eminently suitable for use as organocatalysts. With the increasing importance of organocatalysis, it is foreseeable that in the future pharmaceutical companies may have to consider extending a drug s patent protection to include catalytic activity. 

Easter Island (Rapa Nui) first discovered and characterized by Sehgal in 1975 (38), Initially identified as an antifungal agent, the compound was subsequently found to posses potent immunosuppressive activities, initially demonstrated through its ability to prevent adjuvant-induced arthritis and experimental allergic encephalomyelitis in rodent models. As a potent immunosuppressive agent, sirolimus has been developed and marketed by Wyeth Pharmaceuticals for the prevention of renal transplant rejection (Rapamune ) (39). 

Many of the biological and pharmaceutical compounds are chiral In nature. These compounds contain at least one asymmetric carbon atom or are molecularly as5mimetric. These have identical physical and chemical properties and differ only in their spatial configuration or in their optical properties. It is usual that Just one isomeric/enantiomeric form of these compounds is biologically active. For example, it is the L-isomers of amino acids which one finds in proteins and the D-isomer is biologically rejected. It is the D-glucose, not L-glucose that has been preferred by life. 

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