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Peroxisome proliferator-activated receptor pioglitazone

Thiazolidinediones (PPARy-agonists) Thiazolidine-diones ( pioglitazone, rosiglitazone) lower blood glucose levels in animal models of insulin resistance and also in insulin resistant patients. They are agonists of the peroxisome proliferator-activated receptor y (PPARy). Because they enhance the effect of insulin and reduce serum insulin levels in insulin resistant patients, thiazolidinediones are usually referred to as insulin sensitizers . [Pg.425]

Thiazolidinediones (synonyms glitazones, insulin sensitizers rosiglitazone, pioglitazone) are a novel class of oral antidiabetic drugs that activate the transcription factor peroxisome proliferator-activated receptor (PPARy). Thiazolidinediones ameliorate insulin resistance in obese animal models and in individuals... [Pg.635]

Konturek, P. C., Brzozowski, T., Kania, J., Konturek, S. J., Kwiecien, S., Pajdo, R., and Hahn, E. G. (2003). Pioglitazone, a specific ligand of peroxisome proliferator-activated receptor-gamma, accelerates gastric ulcer healing in rat. Eur.J. Pharmacol. 472, 213-220. [Pg.175]

Peroxisome proliferator-activated receptor agonists PPARa agonist Ciglitazone Pioglitazone PPARy agonists WY 14.643... [Pg.391]

Thiazolidinediones (Gamma-PPAR (peroxisome proliferator-activated receptor) agonists) Pioglitazone, Rosiglitazone... [Pg.469]

Enhancers of insulin action, such as peroxisome proliferator-activated receptor (PEAR) ligands [e.g., troglitazone (withdrawn from clinical use), pioglitazone, rosi-glitazone], retinoid X receptor (RXR) modulators, and protein tyrosine phosphatase IB (PTP IB) inhibitors... [Pg.92]

S.J. Konturek, and E.G. Hahn. Pioglitazone, a Specific Ligand of the Peroxisome Proliferator-Activated Receptor y Reduces Gastric Mucosal Injury Induced by Ischaemia/ Reperfusion in Rat. 38. 468-476 (2003). [Pg.122]

The antidiabetic thiazolidinedione activators of peroxisome proliferator-activated receptors (PPARs) include rosiglitazone (100, Avandia ), pioglitazone (Actos ) and troglitazone (Rezulin ), and all include a benzyl-linked thiazolidinedione ring which is constructed via a Knoevenagel condensation between thiazolidinedione 51 and a substituted benzaldehyde such as 98 under Cope conditions. ... [Pg.494]

See other pages where Peroxisome proliferator-activated receptor pioglitazone is mentioned: [Pg.257]    [Pg.65]    [Pg.359]    [Pg.248]    [Pg.225]    [Pg.100]    [Pg.50]    [Pg.264]    [Pg.10]    [Pg.660]    [Pg.647]    [Pg.688]    [Pg.647]    [Pg.248]    [Pg.421]    [Pg.6]    [Pg.363]    [Pg.523]    [Pg.356]    [Pg.86]    [Pg.307]    [Pg.171]    [Pg.432]    [Pg.1331]    [Pg.1375]    [Pg.400]    [Pg.228]    [Pg.185]    [Pg.228]    [Pg.120]    [Pg.120]   
See also in sourсe #XX -- [ Pg.188 , Pg.194 , Pg.202 ]



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Active receptor

Peroxisome proliferation-activated

Peroxisome proliferation-activated receptor

Peroxisome proliferator activator

Peroxisome proliferator activator activators

Peroxisome proliferator receptor

Peroxisome proliferator-activated receptor activation

Peroxisome proliferators activator receptor

Peroxisome proliferators-activated

Peroxisomes

Peroxisomes proliferation

Proliferator-activated receptor

Receptor activation

Receptor activity

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