Peripheral primitive neuroectodermal

Ambros, I. M., Ambron, P. F., and Strehl, S. (1991) M1C2 is a specific marker for Ewing s sarcoma and peripheral primitive neuroectodermal tumors. Cancer 67, 1886-1893. 

Machen SK, Fisher C, Gautam RS, et al. Utility of cytokeratin subsets for distinguishing poorly differentiated synovial sarcoma from peripheral primitive neuroectodermal tumour. Histopathology. 1998 33 501-507. 

Jones JE, and McGill T. Peripheral primitive neuroectodermal tumors of the head and neck. Arch Otolaryngol Head Neck Surg. 1392 121(12) 1392-1395. 

Nikitakis NG, Salama AR, O Malley Jr BW, et al. Malignant peripheral primitive neuroectodermal mmor-peripheral neuroepithelioma of the head and neck a clinicopathologic study of five cases and review of the literature. Head Neck. 2003 25(6) 488-498. 

Banerjee SS, Agbamu DA, Eyden BP, et al. Clinicopathological characteristics of peripheral primitive neuroectodermal tumor of skin and subcutaneous tissue. Histopathology. 1997 31 355-366. 

Lawlor ER, Mathers JA, Bainbridge T, et al. Peripheral primitive neuroectodermal tumors in adults documentation by moleculat analysis./ Clin Oncol. 1998 16 1150-1157. 

Shanfeld RL, Edelman J, Willis JE, et al. Immunohistochemical analysis of neural markers in peripheral primitive neuroectodermal tumors (pPNET) without light microscopic evidence of neural differentiation. Appl Immunohistochem. 1997 5 78-86. 

Kawauchi S, Fukuda T, Miyamoto S, et al. Peripheral primitive neuroectodermal tumor of the ovary confirmed by CD99 immunostaining, karyotypic analysis, and RT-PCR for EWS/FLI-1 chimeric mRNA. Am J Surg Pathol. 1998 22 1417-1422. 

FIGURE 20.40 This peripheral primitive neuroectodermal tumor (pPNET) is diffusely and intensely positive for MIC2. 

Tsuji, S., Hisaoka, M., Morimitsu, Y. et al (1998) Peripheral primitive neuroectodermal tumor of the lung report of two cases. Histopathology, 33, 396-374. 

Liombart-Bosch, A., Pellin, A., Carda, C. et al (2000) soft tissue Ewing s sarcoma-Peripheral primitive neuroectodermal tumor with atypical dear cell pattern shows type EWS.EEV fusion transcript. Diag Mol Pathol, 9, 137-144. 

Seronsen, P.H.B., Liu, X.F., Delattre, O. (1993) Reverse transcriptase PCR amplification of EWS/FLIl fusion transcripts as a diagnostic test for peripheral primitive neuroectodermal tumours of childhood. Diag Mol Pathol, 2, 147-157. 

Clear Cell Sarcoma of the Kidney 443 Rhahdoid Tumor of the Kidney 443 Juvenile Renal Cell Carcinoma 445 Renal Medullary Carcinoma 446 Malignant Hematologic Diseases 446 Peripheral Primitive Neuroectodermal Tumor 446 Metastases 447... 

Peripheral primitive neuroectodermal tumor (pPNET) of the kidney is a very rare entity with high malignant potential and no specific radiological pattern described. The diagnosis is based on histopathology with subsequent demonstration of typical chromosomal translocations of the PNET/ Ewing tumor family (Doerfler et al. 2001 Vicha et al. 2002 Lam et al. 2003). 

Doerfler O, Reittner P, Groell R et al (2001) Peripheral primitive neuroectodermal tumour of the kidney CT findings. Pediatr Radiol 31(2) 117-119... 

Vicha A, Stejskalova E, Sumerauer D et al (2002) Malignant peripheral primitive neuroectodermal tumor of the kidney. Cancer Genet Cytogenet 139(l) 67-70... 

Fetal fibroblasts myometrium vascular smooth muscle fetal myocardium vascular endothelial cells selected reticulum cells of lymphatic organs some CD30+ lymphoid cells (rarely) selected leiomyosarcomas, epithelioid hemangioendotheliomas, epithelioid angiosarcomas, primitive neuroectodermal tumors and Ewing s sarcomas, malignant peripheral nerve sheath tumors, and clear cell sarcomas... 

Anti-CD99 (M) Dako 1 20 MWER Recognition of virtually all primitive neuroectodermal tumors and Ewing s sarcomas labels roughly 50% of synovial sarcomas and malignant peripheral nerve sheath tumors also present in lymphoblastic lymphomas/ leukemias presenting in soft tissue... 

Eolpe AL, Schmidt RA, Ghapman D, et al. Poorly differentiated synovial sarcoma immunohistochemical distinction from primitive neuroectodermal tumors and high-grade malignant peripheral nerve sheath tumors. Am J Surg Pathol. 1998 22 673-6S2. 

Navarro S, Gavazzana AO, Llombart-Bosch A, et al. Gompari-son of Ewing s sarcoma of bone and peripheral neuroepithelioma An immunocytochemical and ulttasttuctural analysis of two primitive neuroectodermal neoplasms. Arch Pathol Lab Med. 1994 118 608-615. 

The ability of melanoma to simulate the appearance of various soft tissue sarcomas is also well documented. These include malignant peripheral nerve sheath tumors, gastrointestinal stromal tumors, epithelioid angiosarcoma, rhabdoid tumors, osteosarcomas, and primitive neuroectodermal tumors, to name a few. The detailed immunophenotypic properties of those lesions are provided elsewhere in this book. However, none of them manifests reactivity for gplOO-related melanocytic markers or tyrosinase, making those markers essential to the differential diagnostic process. 

Dehner LP. Peripheral and central primitive neuroectodermal tumors A nosologic concept seeking a consensus. Arch Pathol Lab Med. E986 EE0 997-E005. 

CMV, cytomegalovirus CNS, central nervous system EMA, epithelial membrane antigen GFAP, glial fibrillary acidic protein HV, herpesvirus NF, neurofilament PML, progressive multifocal leukoencephalopathy PNET, primitive neuroectodermal tumor PNS, peripheral nervous system Mw, microwave starting in cold buffer for time noted. 

Rare case reports exist of carcinosarcomas harboring yolk sac tumor " or neuroectodermal elements (including primitive, peripheral neuroectodermal tumor). > When it has been studied, the immunophenotype of these components has been similar to that described in tumors outside the context of carcinosarcoma. 

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