Periodate, acidic, oxidation with Subject

After reduction of the aldehyde with borohydride, the ester groups of the remaining mono-, di-, and tri-O-acetylated sialic acids that are unaffected by these vigorous conditions of oxidation are hydrolyzed by alkali, the products are subjected to mild oxidation with periodate,... 

In a first step, the TBS ether is subjected to acid cleavage with copper sulfate in acetone containing a catalytic amount of glacial acetic acid. The resulting diol is then protected as an acetunide. Next, the double bond is oxidatively cleaved with sodium periodate and a catalytic amount of osmium tetroxide to give aldehyde 5. 

Phenolic oxidation is known to be effected with sodium periodate or periodic acid to yield o- and p-quinols, quinones and other products, depending on substituents attached to the aromatic ring. 2,4,6-Trimethylphenol (221) was subjected to NaI04 oxidation in 80% aq. AcOH to afford the four products 383, 599, 600 and 601 (10, 17, 28 and 31%, respectively). Of these products, the dimer 601 must be formed from the corresponding cyclohexadienone 602 (Scheme 115) °. ... 

A procedure involving GLC for the quantitative estimation of aldosterone in urine has been described by Bravo and Travis (B19). After preliminary purification and paper chromatography, the aldosterone is oxidized with periodic acid to aldosterone y-lactone which is extracted and subjected to GLC, using aldadiene as an internal standard. Figure 6 shows the GLC peak characteristics obtained for aldosterone y-lactone and aldadiene. The results obtained by this procedure are compared (B19) in Table 5 with those obtained by a double isotope derivative assay (K9). 

In a final study,arabinogalactan B was subjected to a Barry degradation (oxidation with periodate, followed by treatment with phenylhydra-zine-acetic acid). One-third of the L-arabinose was removed as the osazone, as a result of the degradation. Since no furanosidic linkages were hydrolyzed... 

On subjecting a neutral potassium phenolate solution to the action of th electric current they were able to isolate a compound, C H 0 , soluble in alkali and precipitated from such solutions by mineral acids. This latter compound on being oxidized with nitric acid formed picric acid. When allowed to remain in solution in the presence of dilute acids for a prolonged period, it underwent decomposition according to the following equation ... 

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