Performing a One-Sample Test of the Mean

In clinical trial analyses you may want to test the mean for a single population to determine if that value differs from a hypothesized value. For example, let s say that you have the lab test value LDL and you want to know if the change-from-baseline value is significantly different from zero. There are several ways to perform this test in SAS. If you assume the change from baseline for LDL, ldl change, is normally distributed, you can run a one-sample t-test in SAS like this  

The p-value for the f-test can be found in the Probt variable in the pvalue data set. 

PROC UNIVARIATE can also be used to perform the one-sample f-test as follows  

If you do not have the change-from-baseline variable, ldl change, calculated but you have the baseline variable, ldl base, and post-treatment variable, ldl post trt, then you can run this comparison as a paired t-test, like this  

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