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Per-Arnt-Sim

Roberts BJ, Whitelaw ML (1999) Degradation of the basic helix-loop-helix/Per-ARNT-Sim homology domain dioxin receptor via the ubiquitin/proteasome pathway.) Biol Chem 274 36351-36356... [Pg.156]

In addition to the pore domain, it is possible to create homology models of the voltage-sensor and C-terminal domains of hERG. There are also two structures of hERG itself, a crystal structure of the Per-Arnt-Sim (PAS) domain, found within the N-terminus [112], and an NMR solution structure of the S5 to pore helix linker (Turret) [113]. A full list of crystal structures that can be used to create homology models of hERG is shown in Table 16.2. [Pg.449]

Soshilov A, Denison MS (2008) Role of the Per/Arnt/Sim domains in ligand-dependent transformation of the aryl hydrocarbon receptor. J Biol Chem 283(47) 32995-33005. doi 10.1074/jbc.M802414200... [Pg.453]

Pollenz, R.S., H.R. Sullivan, J. Holmes, B. Necela and R.E. Peterson. Isolation and expression of cDNAs from rainbow trout (Oncorhynchus mykiss) that encode two novel basic helix-loop-helix/PER-ARNT-SIM (bHLH/PAS) proteins with distinct functions in the presence of the aryl hydrocarbon receptor. Evidence for alternative mRNA splicing and dominant negative activity in the bHLH/PAS family. J. Biol. Chem. 271 30886-30896, 1996. [Pg.39]

Most of the research on xenobiotic receptors has been conducted in mammalian systems. These studies have identified three families of proteins as having important roles in regulating the response to xenobiotic chemicals (Table 1). The aryl hydrocarbon receptor (AHR), a member of the basic helix-loop-helix Per-ARNT-Sim (bHLH-PAS) family of transcription factors, is well known for its role in the altered gene expression and toxicity elicited by chlorinated dioxins and related planar halogenated aromatic hydrocarbons (PHAHs) as well as certain polynuclear aromatic hydrocarbons (PAHs)114 188 244. Several members of the nuclear/steroid... [Pg.192]

Karchner, S.I., W.H. Powell and M.E. Hahn. Identification and functional characterization of two highly divergent aryl hydrocarbon receptors (AHR1 and AHR2) in the teleost Fundulus heteroclitus. Evidence for a novel subfamily of ligand-binding basic helix-loop-helix Per-ARNT-Sim (bHLH-PAS) factors. J. Biol. Chem. 274 33814-33824, 1999. [Pg.221]

PYP (photoactive yellow protein) PAS (Per/Arnt/Sim) domain LOV (light/oxygen/voltage... [Pg.134]

Fig. 8.2 Schematic illustration of the interdomain signal transmission in a dimeric oat phytochrome. Q Quail box. PAS Per-Arnt-Sim motif. Q and PAS constitute the regulatory core region. HD Histidine kinase-related domain. PKSl Phytochrome kinase... Fig. 8.2 Schematic illustration of the interdomain signal transmission in a dimeric oat phytochrome. Q Quail box. PAS Per-Arnt-Sim motif. Q and PAS constitute the regulatory core region. HD Histidine kinase-related domain. PKSl Phytochrome kinase...
See other pages where Per-Arnt-Sim is mentioned: [Pg.890]    [Pg.308]    [Pg.221]    [Pg.140]    [Pg.543]    [Pg.161]    [Pg.890]    [Pg.1722]    [Pg.73]    [Pg.375]    [Pg.576]    [Pg.673]    [Pg.79]    [Pg.262]    [Pg.524]    [Pg.92]    [Pg.2189]    [Pg.588]    [Pg.158]    [Pg.2531]    [Pg.2532]    [Pg.409]   
See also in sourсe #XX -- [ Pg.449 ]



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