Peptides thermodynamic aspects

Thermodynamic Aspects of the Mixing of Mono-Amides and Poly-Peptides with Water, reproduced in Colloidal Dispersions and Micellar Behavior K. L. MitteOL Ed., ASC Symposium Series, Vol. 9, (1975) p. 288 co-authors P. Assarsson and N. Y. Chen. 

II. Thermodynamic Aspects of Peptide Synthesis 1. Heat and Free Energy of Formation... 

In this review we will consider the different aspects of the prebiotic chemistry of amino acid and peptides. It includes a survey of recent advances in amino acid formation pathways, the question of peptide bond formation considered both from the synthetic point of view and by taking into account the thermodynamic constraints on peptide bond formation and the availability of activated forms of amino acids and/or activating agents. The question of the emergence of the genetic code will be considered in the context of a co-... 

We summarise recent work on computer modelling and simulation of proteins involved in bioenergetic processes and in peptide-membrane interactions. Homology modelling, electrostatic calculations and conformational analysis of a photosynthetic reaction centre protein are described. Bacteriorhodopsin, a light-driven proton pump protein is examined from several aspects, including its hydration and conformational thermodynamics. Finally, we present results on lipid perturbation on interaction with a cyclic decapeptide antibiotic, gramicidin S. 

In Section 4 of Chapter 2, the strong ion-water interaction, in addition to the interionic interaction, was shown to be an influential factor in determining thermodynamic properties of polyelectrol3 e solutions. The hydration phenomenon of macroions is a typical example of the former type of interaction, but its quantitative aspect could not be discussed in terms of the mean activity coefficient. The measurement of the partial molal voliime of polyelectrol3 es is interesting because this volumetric quantity can furnish quantitative information on the hydration on one hand a because it is the pressure dernmtive of the mean activity coefficient on the other. In spite of its importance, however, only a few measurements have so far b n reported for synthetic polyelectrofytes (75, 79, 50). [For a review of the volumetric study of proteins, amino acids, and peptides, an earlier work by Cohn and Edsall should be consulted (5/)]. 

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