Peptide growth factors

O Neill, C., Riddle, P., Rosengurt, E. (1985). Stimulating the proliferation of quiescent 3T3 fibroblasts by peptide growth factors or by agents which elevate cellular cyclic AMP level has opposite effects on motility. Expt. Cell Res. 156.65-78. 

Growth factor receptors located on the cell surface are often water-soluble because the peptide growth factors cannot diffuse across the plasma membrane... 

Table 7.1. Overview of some pol5 peptide growth factors. Many can be grouped into families on the basis of amino acid sequence homology, or the cell t5q)es affected. Most growth factors are produced by more than one cell type and display endocrine, paracrine or autocrine effects on target cells by interacting with specific cell surface receptors...

It was observed that for CCK and related peptides sulfation of the tyrosine residue is essential for triggering the full hormonal response.131 32 More recently, additional sulfated peptides have been identified as CCK-58, 135 phytosulfokinine-a, as peptide growth factor in plants 136 as well as various toxins from Conus venom. 137138 This observation has fostered intensive research to develop synthetic methods for efficient production of tyrosine O-sulfated peptides by chemical and enzymatic approaches. 

This review will describe the biological functions and regulation of the recently identified cytokines—interleukins, chemokines, and peptide growth factors—their intracellular signal transduction and role in certain diseases, and different cytokine assay methods and their clinical applications. 

Timpe LC, Fantl WJ. Modulation of a voltage-activated potassium channel by peptide growth factor receptors. J Neurosci 1994 14 1195-1201. 

Peptide Growth Factor Expression in Response to Cardiac Hypertrophy... 

A Synopsis of the Cellular and Molecular Events of Cardiac Hypertrophy and Potential Contribution of Peptide Growth Factors... 

Calderone, A., Takahashi, N., Izzo, N.J., Thaik, C.M., and Colucci, W.S. 1995. Pressure- and volume-induced left ventricular hypertrophies are associated with distinct myocyte phenotypes and differential induction of peptide growth factor mRNAs. Circulation 92 2385-2390. 

Parker, T.G., Packer, S.E., and Schneider, M.D. 1990. Peptide growth factors can provoke fetal contractile gene expression in rat cardiac myocytes. J. Clin. Invest. 85 507-514. 

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