Peptide-MHC complex

Valitutti, Muller S, Celia M, Padovan E and Lanzavecchia A 1995 Serial triggering of many T-cells by a few peptide-MHC complexes Nature 375 148-51... 

Madden, D.R., Garboczi, D.N., Wiley, D.C. The antigenic identity of peptide-MHC complexes a comparison of the conformation of five viral peptides persented by HLA-A2. Cell 75 693-708, 1993. 

The most clearly defined factors in determining the differentiation of Th responses are the cytokines present during T cell receptor engagement of the peptide MHC complex. IL-12 and IFN-y are important in the development of type 1 responses (Hsieh et al., 1993 Seder et al, 1993), while IL-4 is important in the induction of type 2 responses (Abishira-Amar et al., 1992 Seder et al., 1992). The importance of these cytokines in influencing... 

D. R. Madden.The three-dimensional structure of peptide-MHC complexes. Annu Rev Immunol, 13, 587-622, 1995. 

Vetoing. Elimination ( - apoptosis) of the self-peptide-MHC complex recognizing lymphocyte by the self-peptide presenting (veto) cell. A less important regulatory mechanism of selftolerance. 

The immune system also makes use of the ubiquitin-mediated pathway in the response to altered self-cells, particularly virus-infected cells. Viral proteins within the cytosol of infected cells are ubiquitinated and then degraded in pro-teasomes specially designed for this role. The resulting antigenic peptides are transported to the endoplasmic reticulum, where they bind to class I major histocompatibility complex (MHC) molecules within the ER membrane. Subsequently, the peptide-MHC complexes move to the cell membrane where the antigenic peptides can be recognized by c3rt otoxic T lymphocytes, which mediate the destruction of the Infected cells. 

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