MHC peptides

To date, there has not been a reported structure determination of a class 11 MHC-peptide-TCR complex. However, T-cell receptors that recognize class... 

I MHC-peptide complexes and those that recognize class 11 MHC-peptide complexes utilize the same set of Va and Vp genes, and the principal feature that defines the site of class 1 MHC-TCR interaction, the cleft formed by the a and az subunits of the MHC molecule, is shared by both class 1 and class... 

OSN responses to peptides were found to be highly sensitive, with thresholds down to 10 11M, although they were around two orders of magnitude less sensitive than VSN responses (Spehr et al. 2006). OSN responses to MHC peptide ligands also displayed a different dependence on anchor residues. Whereas replacement of anchor residues with alanines abolished the responses of VSNs, it shifted the stimulus response curve of around two thirds of the OSNs, making them less sensitive by approximately two orders of magnitude. However, OSNs still failed to respond to the scrambled version of the peptide or a mixture of its constituent amino acids (Spehr... 

There is clear evidence that highly sensitive receptors for MHC peptide ligands can be found in both the main olfactory and vomeronasal systems of mice. 

Boehm, T. and Zufall, F. (2006) MHC peptides and the sensory evaluation of genotype. Trends Neurosci. 29, 100-107. 

Milinski, M., Griffiths, S., Wegner, K., Reusch, T., Haas-Assenbaum, A. and Boehm, T. (2005) Mate choice decisions of stickleback females predictably modified by MHC peptide ligands. Proc. Natl. Acad. Sci. USA 102, 4414-4418. 

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