2-pentanone, 4-Hydroxy-4-methyl

Synonyms AI3-00045 BRN 1740440 Caswell No. 280 CCRIS 6177 DAA Diacetone Di-acetonyl alcohol Diketone alcohol Dimethylacetonyl carbinol EPA pesticide chemical code 033901 4-Hydroxy-2-keto-4-methylpentane 4-Hydroxy-4-methylpentanone-2 4-Hydroxy-4-methylpentan-2-one 4-Hydrojg -4-methyl-2-pentanone 2-Methyl-2-pentanol-4-one NSC 9005 Pyranton Pyranton A Tyranton UN 1148. 

In exploring various synthetic methods for the preparation of 1,2-oxaphospholene 2-oxides we investigated the reaction of diacetone alcohol (4-hydroxy-4-methyl-2-pentanone) with methyl and phenylphosphonous dichloride, which was reported (1) to proceed as shown in eq (1) to give 2,3,3,5-tetramethyl-l,2-oxaphos-phol-4-ene 2-oxide or the corresponding 2-phenyl derivative. 

Synonyms/Trade Names Diacetone, 4-Hydroxy-4-methyl-2-pentanone, 2-Methyl-2-pentanol-4-one... 

In a similar way, dl-2-(q-hydroxyalkyl)- and 2-(a-alkoxycarbonyl)-4-methyl-5-(/3-hydroxyethyl)thiazoles were synthetized from the corresponding thioamides and 4-hydroxy-3-bromo-2-pentanone (615). 

Hydroxy 2 methyl pentanoic acid (60% from 2 pentanone)... 

Diacetone Alcohol. Diacetone alcohol (DAA) (4-hydroxy-4-methyl-2-pentanone) is a colorless, mild smelling Hquid which is completely miscible with water and most organic solvents. It is the simplest aldol condensation product of acetone, and because of its keto-alcohol functionahes it has special utility in the coatings industry where it is used to dissolve cellulose acetate to give solutions with high tolerance for water (115). 

Hydroxy-4-methyl-2-pentanone [I23-42-2J M 116.2, b 166 , d 0.932, n 1.4235, n 1.4213. Loses water when heated. Can be dried with CaS04, then fractionally distd under reduced pressure. 

Metalation ofa-sulfinyl dimethylhydrazones with terf-butylmagnesium bromide, butyllithium or lithium diisopropylamide, and reaction of the generated azaenolates with aldehydes, provides aldol adducts (e.g., 6) as mixtures of diastereomers. Reductive desulfurization leads to fi-hydroxy dimethylhydrazones (e.g., 7) which are cleaved to the desired /(-hydroxy ketones in 25% overall yield10 u. The enantiomeric excesses are about 50%, except for (- )-3-hydroxy-4-methyl-1-phenyl-1-pentanone (8) which was obtained in 88% ee. 

By way of example, consider the first-order decomposition of 4-hydroxy-4-methyl-2-pentanone ( diacetone alcohol ) in a reaction that is catalyzed by hydroxide ions, carried out at constant [OH-] 6... 

DDVP, see Dichlorvos Diacetone alcohol (4-hydroxy-4-methyl-2-pentanone) 8.5... 

Hydroxy-4-methyl-2-pentanone, see 2-Hydroxypropyl acrylate Oiacetone alcohol 0.5 2.8 ... 

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