Penicillins Chloroquine

Chloroquine (Aralen) is also used in die treatment of extraintestinal amebiasis (see section on Amebicides). Doxycycline is also used to treat infections caused by Neisseria gonorrhoeae, Treponema pallidum, Listeria monocytogenes, Clostridium, and Bacillus anthracis when penicillin is contraindicated. Quinine also may be used for die prevention and treatment of nocturnal leg cramps. 

Studies of chloroquine used in combination with antibiotics showed an antagonistic effect with penicillin but a synergistic effect with chlortetracycline. Urinary tests after single doses of ampicUhn 1 g and chloroquine 1 g showed a significant reduction in the systemic availability of the ampicillin. 

Clinically important, potentially hazardous interactions with acitretin, aldesleukin, aminoglycosides, amiodarone, amoxicillin, ampicillin, aspirin, bacampicillin, bismuth, carbenicillin, chloroquine, cisplatin, cloxacillin, co-trimoxazole, dapsone, demeclocycline, dexamethasone, diclofenac, dicloxacillin, etodolac, etoricoxib, etretinate, fenoprofen, flurbiprofen, folic acid antagonists, haloperidol, hydrocortisone, ibuprofen, indomethacin, influenza vaccines, ketoprofen, ketorolac, lithium, magnesium trisalicylate, meclofenamate, mefenamic acid, methicillin, mezlocillin, minocycline, nabumetone, nafcillin, naproxen, NSAIDs, omeprazole, oxacillin, oxaprozin, oxytetracycline, paromomycin, penicillin G, penicillin V, penicillins, phenylbutazone, piperacillin, piroxicam, polypeptide antibiotics, prednisolone, prednisone, probenecid, procarbazine, rofecoxib, salicylates, salsalate, sapropterin, sulfadiazine, sulfamethoxazole, sulfapyridine, sulfasalazine, sulfisoxazole, sulindac, tazobactum, tenoxicam, tetracycline, ticarcillin, tolmetin, trimethoprim, vaccines... 

Risk of bleeding or hemorrhage is increased with concommitant administration of aspirin, ibuprofen, anticoagulants/thrombolytics, dextran, phenylbutazone, indomethacin, dipyridamole, several penicillins and cephalosporins, valproic acid, divalproex, plicamycin, methimazole, propylthiouracil, probenecid, hydroxychloroquine, chloroquine. Decreased anticoagulation effect with digitalis, tetracyclines, antihistamines, nicotine. 

Fig. 3 Organometallic complexes of known organic antiproliferation agents designed to overcome drug resistance a ferrocenyl-penicillin derivatives b ferrocenyl-cephalosporin derivatives c rhodium chloroquine complex d ferrocenjd-chloroquine derivative e iri-dium-COD-pentamidine complex...

Hydrocortisone, prednisone, fludrotisone, triamcinolone, dexamethasone, betamethasone Penicillins, cephalosporins, vancomycin, bacitracin, polymycins, tetracyclines, chloramphenicol, erythromycin, streptomycin Quinacrine, chloroquine, quinine Nystatin, gentamicin, miconazole, tolnaftate, undecyclic acid and its salts Vidarabine, acyclovir, ribarivin, amantadine hydrochloride, iododeoxyuridine, dideoxyur-idine, interferons... 

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