Phenoxymethyl penicillin potassium

Phenoxymethyl penicillin potassium, 7,249 Phenylephrine hydrochloride, 3,483 Piperazine estrone sulfate, 5, 375 Primidone, 2,409... 

IR spectrum of phenoxymethyl penicillin potassium. Obtained as a KBr disc. 

Figure 2 Dissolution characteristics of potassium phenoxymethyl-penicillin pure drug and several formulations available on the German market according to the test conditions given in Table 3 (A) At acid pH (the pH used to generate the data shown here was pH 1.2 rather than pH 2 as indicated in the Table) and (B) at pH 6.8.

Potassium phenoxymethyl penicillin is a white, practically odorless,crystalline powder. 

One mg. of potassium phenoxymethyl penicillin represents 1530 phenoxymethyl penicillin units2. 

The infrared spectrum of phenoxymethyl penicillin (free acid) is number 88 in Hayden s compilation of spectra measured on a Perkin-Elmer Model 21 sodium chloride prism spectrophotometer. Infrared spectra of fourteen penicillins in the 1580 to 1880 cm-1 region are discussed by Ovechkin4. Figure 1 is the spectrum of the Squibb Primary Reference Substance of potassium phenoxymethyl penicillin recorded as a potassium bromide... 

Figure 1. Infrared Spectrum. Potassium Phenoxymethyl Penicillin Squibb Primary Reference Substance 1.5 mg/300 mg KBr...

Structural assignments have been made for each peak in the proton magnetic resonance spectrum of sodium phenoxymethyl penicillin (fourth line of Table 5 in reference 5) by Green and co-workers. Proton resonance lines were measured in D2O solution at 38°,with either t-butyl alcohol or sodium 3-(trimethylsilyl) propane-l-sulfonate (assumed to be 2 cycles per second below Me Si) as the internal standard, with the results referred to tetramethylsilane (Me4Si=10.Ot). Cohen and Puar made structural assignments for the peaks of potassium phenoxymethyl penicillin measured in D2O solution at 33° with the results referred to tetramethylsilane as the external standard (Me Si O. Ot). Figure 2 is the spectrum of the Squibb Primary Reference Substance from which proton assignments were made . Spectra in both laboratories were measured on Varian A-60 spectrophotometers. 

Andersen 14 has also shown concern about the importance of slit width on the ultraviolet spectrum of potassium phenoxymethyl penicillin. 

Mathews and his coworkers 8 described an unusual behavior for samples of freeze-dried potassium benzylpenicillin and potassium phenoxymethyl penicillin. These samples absorbed moisture from the air up to a maximum content of 7-14 per cent. Then the samples suddenly contracted in volume and began to lose weight until they had returned to their original weight. 

For purification of the Squibb Primary Reference potassium phenoxymethyl penicillin,the starting material was dissolved in water and crystallized by the addition of a saturated potassium acetate solution. These crystals were then redissolved in water, diluted with butanol, and crystallized again by an azeotropic vacuum distillation to yield the final product Purification and isolation of the potassium salt were the subjects of two Czechoslovakian patents62, 63. 

Staphylococcus aureus 6538P for the determination of potency of potassium phenoxymethyl penicillin. The aureus 6538P strain is the same as S. aureus 209P. 

Potassium Phenoxymethyl Penicillin John M. Dunham Pages 249-300... 

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