8-Peltatin

Podophyllum resin, an alcoholic extract of Podophyllum peltatum, commonly known as mandrake root or May apple, is used in the treatment of condyloma acuminatum and other verrucae. It is a mixture of podophyllotoxin, and peltatin, desoxypodophyllotoxin, dehydropodophyllotoxin, and other compounds. It is soluble in alcohol, ether, chloroform, and compound tincture of benzoin. 

Dysosma pleiantha (Hance) Woodson Pa Jiao Lian (rhizome) Podophyllotoxin, astragalin, peltatin, etoposide, hyperin, deoxypodophyllotoxin.33 Treat condyloma acuminata, exophytic warts. 

According to investigations made by Graffi and coworkers,21,41,42 when /J-peltatin A [l,2,3,4-tetrahydro-2-(hydroxymethyl)-6,7-(meth-ylenedioxy)-4-(3,4,5-trimethoxyphenyl)naphthalene-3-carboxylic 3.21-lactone]-8-yl) a-L-arabinofuranoside (1) is injected43 into a mouse with... 

The lignan constituents of the two roots are the same, but the proportions are markedly different. The Indian root contains chiefly podophyllotoxin (Figure 4.21) (about 4%) and 4 -demethylpodophyllotoxin (about 0.45%). The main components in the American root are podophyllotoxin (about 0.25%), p-peltatin (about 0.33%) and a-peltatin (about 0.25%). Desoxypodophyllotoxin and podophyllotoxone are also present in both plants, as are the glucosides of podophyllotoxin, 4-demethylpodophyllotoxin, and the peltatins, though preparation of the resin results in considerable losses of the water-soluble glucosides. 

Berlin, J., Wray, V., Mollenschott, C. and Basse, R (1986) Formation of (J-peltatin-A methylether and coniferin by root cultures of Linumflavum.. Nat. Prod., 49, 435-9. 

Kranz, K. and Petersen, M. (2003) fi-Peltatin 6-O-methyltransferase from suspension cultures of Linum nodiflorum. Phytochemistry, 64,453-8. 

The resin prepared from the dried rhizome and roots of Podophyllum peltatum contains podophyllotoxin, a-pelta-tin, and P-peltatin. When apphed topically, it is a strong irritant to the skin and mucous membranes and can lead to poisoning because of systemic absorption. When taken by mouth, it has a drastic laxative action and produces violent peristalsis. Ingestion of large doses can result in... 

A limited clinical trial of podophyllotoxin and a co-occurring lignan, a-peltatin, was carried out in the early 1950s, but although some short-lived responses were observed, the general toxicity of the two compounds precluded further studies. At about the same time (1954), the Swiss pharmaceutical company Sandoz embarked on a programme of chemistry directed towards the... 

The methyl ether (23) was compared with analogous known lignans. The H-NMR spectra of compound (2 3) differed from that of dehydro- / -peltatin methyl ether (24) which has the methoxy group at the C-8 position (ref. 25) and from that of dehydrohernandin (25) which has the methoxy group at the C-5 position (ref. 

From the above facts, compound (15) was presumed to be tetrahydronaphtha-lene-type lignan with a trimethoxyphenyl group, a methoxy group and a methyle-nedioxy group. A known lignan with the same molecular formula and functional groups was reported as / -peltatin A methyl ether (3 6 ) (ref. 37), mp 162 — 163 C,... 

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