Pegylated polymers gene delivery

The enormous potential of enzymes has been recently applied to polymer material synthesis and modifications. This recent application has made biocatalysis a popular topic for polymeric research in academia and industry. Enzyme catalysis has provided a new synthetic strategy for useful polymers most of which are otherwise very difficult to produce by conventional chemical catalysis. This paper overviews our recent work on the use of a variety of eu2ymes in the synthesis of novel pegylated multifunctional polymers for applications in drug and gene delivery. 

In addition, the polymer-coated adenovirus particles were able to shield against antibody recognition. In another approach, the PEGylation of the adenovirus capsid protein prolonged transgene expression after systemic delivery of El-deleted adenovirus, and allowed partial readministration with native virus (50). Adenovirus has been explored as vector for the treatment of cystic fibrosis (51), for Duchenne muscular dystrophy (52), to deliver tumor suppressor genes for cancer treatment... 

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