PEGMA methacrylate

Pich and coworkers synthesized microgels by free-radical co-polymerization of vinyl caprolactam and acetoacetoxyethyl methacrylate (AAEM) in the presence of methoxy-capped PEGMA macromonomers [88], It has been reported that variation of the amount of PEG macromonomer or the length of the PEG chain provides effective control of the microgel diameter in the range 60-220nm (Fig. 6). 

Graft copolymers were prepared by both classical strategies, that is, from enzymatically obtained macromonomers by subsequent chemical polymerization and by enzymatic grafting from hydroxyl functional polymers. Kalra et al. studied the synthesis of PPDL graft copolymers from macromonomers, which were obtained by the enzymatic ROP of pentadecalactone (PDL) from hydroxyethyl methacrylate (HEMA) and polyethylene glycol) methacrylate (PEGMA) [40]. Subsequently graft copolymers were obtained by free radical polymerization of the macromonomers. A similar approach was published by Srivastava for the HEMA-initiated enzymatic ROP of CL and subsequent free radical polymerization [41]. 

The chain ends of the star polymers can be functionalized. So it is possible to link these sites and form networks or gels of stars. Depending on the chemical nature of the chain end, the crosslinking can be permanent or stimuli-switchable. Patrick-ios et al. [105] have prepared crosslinked double hydrophilic star copolymers made from methacrylic acid (MAA) and poly(ethyleneglycol methacrylate) (PEGMA). Meyer et al. [106] synthesized photocrosslinkable PMAA stars, which could serve as well-defined model polyelectrolyte networks. The polyelectrolyte stars can also be used as template for some nanomaterials. Want et al. [107] prepared strong anionic polyelectrolyte stars by sulfonation of the PS stars. They were used as the template for the preparation of conducting polyaniline. 

Monomers 4VP, 4-vinylpyridine NIPAAm, jV-isopropylacrylamidc AA, acrylic acid PEGMA, poly (ethylene glycol) methacrylate SPE, MAI-dimethyl-AW2-methacryloyloxycthyl-/V-0-sulfopropyl)amm<>-nium betaine AMPS, 2-acrylamido-2-methyl-l-propanesulfonic acid qDMAEMA, quaternary 2-dimethylaminoethyl methacrylate St, styrene HEMA, 2-hydroxyethyl methacrylate HEA, 2-hydro-xyethyl acrylate DMAEMA, 2-dimethylaminoethyl methacrylate MAA, methacrylicacid NaSS sodium p-styrene sulfonate AC, [(2-acryloyloxy)ethyl]trimethyl ammonium chloride GMA, glycidyl methacrylate NVP, jV-vinylpyrrolidone MAn, maleic anhydride BVE n-butyl vinyl ether AAm, acrylamide DEAAm, MA-diethylacrylamidc DMAAm, MA -dimethylacrylamidc MMA, methyl methacrylate. 

Finally, SIP of polyethylene glycol methyl ether methacrylate (PEGMA) was carried out, and PS/Poly(PEGMA) segregated binary brashes were prepared. SIP ATRP of PEGMA was carried out with maximum precaution to avoid oxygen. For this purpose, CuBr (80.3 mg, 0.56 mmol), CuBr2 (50 mg,... 

Production of nonfouUng polymer surfaces has been achieved by radiation-induced grafting of poly(ethylene glycol) methyl ether methacrylate (PEGMEM) and poly(ethylene glycol) methacrylate (PEGMA) with 2-hydroxyethyl methacrylate (HEMA) onto silastic films (Sun et al. 1986). 

PEGMA Poly(ethylene glycol) monomethyl ether methacrylate... 

Fig. 16 Overall conversion versus (a) time and (b) number-average molar mass, M , and poly-dispersity index, A/w/Afn (the line represents the theoretical M ) for the nitroxide-mediated surfactant-free emulsion copolymerizations of methyl methacrylate and styrene in the presence of poly(PEGMA-ct>-MAA-co-styrene)-SGl macroalkoxyamines of different molar masses triangles 9400, and squares 44(X)gmol ) [145]...

Figure 14 Fluorescent conjugates from BSA macroinitiators, (a) native BSA, (b) BSA-macroinitiator, (c) BSA-poly(dimethylaminoethyl methacrylate-co-rhodamine), (d) BSA-poly(PEGMA-co-rhodamine), (e) BSA-poly(PEGMA-co-rhodamine) illuminated under UVat302 nm. Reprinted with permission from Nicolas, J. San Miguel, V. Mantovani, G. Haddelton, D. M. Chem. Commun. 2006, 42, 4697 699. Copyright 2006 The Royal Society of Chemistry.

In an expanded study, Fournier et al. used RAFT to make random N,N-(dimethyIamino)ethyI methacrylate (DMAEMA) and poly(ethylene glycol) methyl ether methacrylate (PEGMA) copolymers utilizing their automated platform. Since both of... 

AbA acrylated abietic acid, APS (NH4)2S20g, ARGET activators regenerated by electron transfer, t-BA tert-Butyl acrylate, CL e-caprolactone, DEAEMA 2-(diethylamino)ethyl methacrylate, DMAEMA iV,lV-dimethyl aminoethyl methacrylate, PEGMA polyfethylene glycol) methyl ether methacrylate, PMMAZO 6-[4-(4-methoxyphenyl azo)phenoxy]hexyl methacrylate, SBMA sulfobetaine methacrylate, St styrene, TEMED JV -tetramethyl ethylene diamine... 

The use of more complex systems such as ternary blends allows the functionalization of the surfaces with varies chemical functionalities. For instance a PS matrix was mixed with two block copolymers, a hydrophobic (PS-b-P5FS) and an amphiphilic polystyrene-b-poly[poly(ethylene glycol) methyl ether methacrylate] (PS-6-P(PEGMA)) copolymer [96], The chemical distribution of the resultant surface pattern implies an enrichment of the holes in the amphiphilic copolymer with an external surface mainly functionalized in the fluorinated copolymer with low surface energy (Scheme lO.lg). Other ternary blends combining incompatible copolymers and homopolymers have been reported leading to more complex topographies and chemical distributions [148],... 

Thermoresponsive Polymers. Poly[(ethylene glycol) methacrylate] (PEGMA) and poly(iV-isopropylacrylamide) (PNIPAam) are well-studied polymers for imparting thermoresponsive properties to cationic vectors. These polymers undergo a phase transition (from random coil to globular form) at a lower critical solution temperature (LCST) near the... 

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