Pathway-specific regulators

Uguru GC, Stephens KE, Stead JA, Towle JE, Baumberg S, McDowall KJ. (2005) Transcriptional activation of the pathway-specific regulator of the actinorhodin biosynthetic genes in Streptomyces coelicolor. Mol Microbiol 58 131-150. 

Takano E, Kinoshita H, Mersinias V, Bucca G, Hotchkiss G, NihiraT, Smith G, Bibb M, Wohlleben W, Ghater KE, A bacterial hormone (the SGBl extracellular signalling system) directly controls an antibiotic pathway-specific regulator in the cryptic type I polyketide biosynthetic cluster oiStreptomyces coelicolor A5 2), Mol Microbiol 56 465 79, 2005. 

Recently, the biosynthesis of PKS-NRPS hybrid metabolites has been described. The pathway-specific regulator was expressed under the control of an inducible promoter, which finally resulted in switching on of the silent pathway.88 Although there are many successfully executed examples from academia, there is still a long way to go to transfer the technology into broadly applicable industrial processes. 

CHANG, P.K., The A.spergillus parasiticus protein AFLJ interacts with the aflatoxin pathway-specific regulator AFLR, Mol Genet. Genomics, 2003, 268, 711-719. 

Beyer S, Distler j, Piepersberg W. The str gene Chester for the hinaynthesis of 5 hydroxy-streptomycin in Srreptomyces glaucescens GLA.O (ETH 22794) New operons and evidence for pathway-specific regulation by StrR. Mol Gen Genet 1996 250 775-784. 

Keywords Antibiotic biosynthesis pathways Phosphate and nitrogen control Pathway-specific regulators Streptomyces regulatory mechanisms Two component systems... 

Pathway Specific Regulators Intermediates in the Regulatory Cascades... 

Other Pathway Specific Regulators The LAL and LysR-Type Regulators... 

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