Pathological process approach

A second conceptual approach is a histopathological classification system. This system categorizes disease processes in terms of damage at the tissue and cellular level. This approach focuses on ten fundamental pathological processes (conveniently designated with the THIND mnemonic) ... 

It has been established that the pathological processes of multistep carcinogenesis comprises initiation, promotion, and progression. The natural history of carcinogenesis and cancer provides a strong rationale for a preventive approach to the control of this disease and leads one to consider the possibility of active pharmacological intervention to arrest or reverse the process of carcinogenesis before invasion and metastasis occur. Such intervention is called chemoprevention. Tss... 

In summary, the current therapeutic approach for the treatment of pulmonary hypertension is largely experimental, and the search continues for the ideal therapeutic to produce long-lasting normalization of pulmonary artery pressure by reversing the pathologic process in primary pulmonary hypertension. 

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