Pathogenesis metastasis

Fig. 1. The pathogenesis of metastasis. To produce metastases, tumor cells in a primary neoplasms must complete a series of sequential and selective steps, each of which can be rate limiting because a failure or an insufficiency at any of the steps aborts the process. Reproduced with permission from Fidler, Cancer Research (F5).

W3. Wood, S., Jr., Pathogenesis of metastasis formation observed in the rabbit ear chamber. Arch. Pathol. 66, 550-558 (1958). 

Fidler, 1. J. 2002. The pathogenesis of cancer metastasis the seed and soil hypothesis revisited. Nature Rev. Cancer 3 1-6. 

Mehta P. Potential role of platelets in the pathogenesis of tumor metastasis. Blood. 63 (1984) 55-63. 

Karahatay, S., Thomas, K., Koybasi, S., Senkal, C.E., Elojeimy, S., Liu, X., Bielawski, J., Day, T.A., Gillespie, M.B., Sinha, D., Norris, J.S., Hannun, Y.A., and Ogretmen, B. Clinical relevance of ceramide metabolism in the pathogenesis of human head and neck squamous cell carcinoma (HNSCC) attenuation of C(18)-ceramide in HNSCC tumors correlates with lymphovascular invasion and nodal metastasis. Cancer Lett, 256, 2007, 101-111. 

Vene R, Benelli R, Noonan DM, Albini A HIV-Tat dependent chemotaxis and invasion, key aspects of tat mediated pathogenesis. Clin Exp Metastasis 2000 18 533-538. 

In a few instances the temporary reconstitution of the cell surface can be achieved by using liposomes to carry the missing lipids. This sometimes restores the normal social behaviour of the cells for a time, suggesting a direct role for some glycolipids in cell contact and hence, perhaps, metastasis of tumours. Equally, some alterations in glycolipids seem to have no adverse consequences and so may not be part of the pathogenesis of malignancy. 

Based on the understanding of the pathogenesis of colorectal liver metastasis via portal dissemination, intraportal chemotherapy after primary tumor resection was tested in several phase III trials. Neither a reduction of hepatic progression nor a survival benefit could be unanimously observed, so... 

Deregulation of proliferation pathways and protein synthesis has been strongly implicated in the pathogenesis of cancer and metastasis (Pervin et al. 2008a). 

---