PART 7 BIOORGANIC COMPOUNDS

Bioorganic components in soil include those organic molecules that participate in biochemical reactions, initiate reactions, inhibit the action of other biochemical, or act as antibiotics. Bioorganic chemistry also uses synthesized molecules to study biological processes such as enzyme activity. Often these studies are undertaken to develop a mechanism for the reactions of interest. Bioorganic molecules will be present either as components of the synthesis chain or as part of the degradation products. Whenever a cell lyses, its compounds will be released into the soil solution. 

This book is intended for chemists who are interested in bioorganic and medicinal chemistry. Its aim is to give an overview of the various applications of fluorinated compounds in these areas. Bioorganic and Medicinal Chemistry of Fluorine is divided in two main parts the first one deals with generalities concerning the specific properties of fluorinated compounds and their preparation the second part is dedicated to the different classes of fluorinated compounds involved in bioorganic chemistry and to their biological properties. 

Sabio, M., Jones, K., andTopiol, S. (2008) Use of the X-ray structure of the 32-adrenergic receptor for drug discovery. Part 2 identification of active compounds. Bioorganic S, Medicinal Chemistry Letters, 18, 5391-5395. 

Prado-Prado, R J., Gonzalez-Diaz, H., de la Vega, O. M., Ubeira, R M., Chou, K. C. (2008). Unified QSAR approach to antimicrobials. Part 3 first multi-tasking QSAR model for input-coded prediction, structural back-projection, and complex networks clustering of antiprotozoal compounds. Bioorganic Medicinal Chemistry, 16, 5871. 

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