Olanzapine Citalopram

Thieme, D. Sachs, H. Improved screening capabilities in forensic toxicology by application of liquid chromatography-tandem mass spectrometry, Anal.ChimActa, 2003, 492, 171-186. [hair LC-MS alprazolam dothiepin piritramide cocaine lorazepam lormetazepam clonazepam flimitrazepam bromazepam midazolam flurazepam nitrazepam temazepam medazepam nordazepam diazepam methylclonazepam triazolam oxazepam haloperidol benperidol sulpiride amisulpride mirtazapine citalopram olanzapine paroxetine fluoxetine sertraline zopiclone zolpidem risperidone quetiapine fentanyl pipamperone meperidine buprenorphine propoxyphene pentazocine phenazocine EDDP ... 

Alternatively, the current antidepressant may be augmented (potentiated) by the addition of another agent (e.g., lithium, T3), or an atypical antipsychotic (e.g., risperidone). Risperidone has been shown to be effective in combination with fluvoxamine, paroxetine, or citalopram in treatment-resistant depression. Olanzapine and fluoxetine have been found to be safe and effective in treatment-resistant depression. 

Antidepressants amitriptyline, clomipramine, imipramine, moclobemide, citalopram Antipsychotics olanzapine... 

Olanzapine Valproate Clomipramine Citalopram Isoflurane Clomipramine... 

Ajmaline, alprenolol, amiflamine, amphetamine, aprindine, captopril, chlorpheniramine, cinnarizine, citalopram, clomipramine, clozapine, codeine, desipramine, dolasteron, encainide, flecainide, fluoxetine, fluphenazine, haloperidol, hydrocordone, imipramine, loratidine, methoxyphenamine, 3,4-methylenedioxymethamphetamine, metoprolol, mexiletine, (S)- and (i )-mianserin, nifedipine, olanzapine, omeprazole, oxycodone, perhexiline, phenformin, propaphenone, propranolol, remoxipride, ritonavir, saquinavir, selegiline, tamsulosin, timolol, tomoxetine, tramadol, trifluperidol, zolpidem... 

Antidepressants Fluvoxamlne, a potent inhibitor of the cytochrome P450 enzymes CYP1A2 and CYP2C19 and a moderate inhibitor of CYP3A4, has been reported to cause a 5-10-fold elevation of plasma clozapine concentration. Fluoxetine and paroxetine may also increase plasma clozapine concentrations, while citalopram and sertraline have been reported to cause minimal or no elevation of plasma levels of clozapine. To date, in vivo studies with a combined olanzapine-imipramine regimen have not revealed any pharmacokinetic interactions. 

The manufacturers say that fluoxetine 60 mg daily for 8 days caused an increase of 16% in olanzapine maximum serum levels and a 16% decrease in clearance. These differences were considered to be too small to necessitate dosage adjustments. Similar results were found in a published study. A case report describes a patient who had been taking fluoxetine 80 mg daily for several weeks with no adverse effects who developed the serotonin syndrome within 3 weeks of starting to take olanzapine 5 mg daily. His symptoms resolved after discontinuing the fluoxetine, and he was later able to tolerate a 20 mg daily dose of fluoxetine and olanzapine with no further adverse effects. The serotonin syndrome has also been reported in a patient taking olanzapine, citalopram and lithium, see Olanzapine + Lithium , p.756. 

Another study found that paroxetine, fluoxetine and sertraline increased olanzapine levels by about 32%, but citalopram had no effect. ... 

For a report of the serotonin syndrome in a patient with bipolar affective disorder treated with lithium, citalopram and olanzapine, see Olanzapine + Lithium , p.756. 

Noninterfering amitriptyline, bupropion, citalopram, clomipramine, clozapine, dox-epin, haloperidol, 2-hydroxydesipramine, 2-hydroxyimipramine, imipramine, loxapine, moclobemide, olanzapine, risperidone... 

---