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Parkinson disease etiology

Etiology of Parkinson Disease Genetic and Environmental Factors... [Pg.120]

Tanner CM, Ottman R, Goldman SM, EUenberg J, Chan P, Mayeux R, Langston JW (1999) Parkinson disease in twins An etiologic study. JAMA 281 341-346. [Pg.238]

LeWitt PA. Parkinson s disease Etiologic considerations. In Ahlskog JE, Adler CA, eds. Parkinson s Disease and Movement Disorders Diagnosis and Treatment Guidelines for the Practicing Physician. New York, Humana Press, 2000 91-100. [Pg.1087]

RESPONSE We do not understand all there is to know about the mechanisms of MPTP neurotoxicity, but it seems to involve MPP+, which is potentially cytotoxic to all cells but that attains toxic concentrations after MPTP administration only in cells that concentrate MPP+. Dopamine apparently is not involved in the neurotoxic effects of MPTP. I am attracted to the idea that dopamine itself may be involved in the etiology of Parkinson s disease, that dopamine neurons may be at risk because of the nature of their neurotransmitter. [Pg.350]

Uncomplicated, with delirium, with delusions, and with depressed mood Dementia due to HIV disease Dementia due to head trauma Dementia due to Parkinson s disease Dementia due to Huntington s disease Dementia due to Pick s disease Dementia due to Creutzfeldt-Jakob disease Dementia due to a specific general medical condition (specify) Dementia that is substance-induced Dementia due to multiple etiologies Dementia not otherwise specified... [Pg.514]

Imipramine is the primary representative of typical tricyclic antidepressants. It acts by blocking the mechanism of renptake of biogenic amines. It does not inhibit MAO activity. Imipramine lessens sadness, lethargy, improves mood, and improves the mental and overall tone of the body. It is nsed in depression of varions etiology accompanied by motor cinmsiness and ennresis in children and Parkinson s disease. Primary synonyms of this drag are tofranil, snrplix, imizin, melipramin, and others. [Pg.105]

Olanow CW and Tatton WG. Etiology and pathogenesis of Parkinson s disease. Annu Rev Neurosci 1999 22 123-144. [Pg.373]

A principal interest in our laboratory is the molecular characterization of CNS receptor sites of the neurotransmitter dopamine (DA, 5). These sites are strongly implicated in the biochemical etiology of schizophrenia and Parkinson s Disease, as well as other diseases of the CNS (50,51). Thus, the rank order of clinical potency of antipsychotic drugs (neuroleptics) correlates with the affinity of these drugs for dopaminergic sites (52,53), It is also well established that Parkinson s disease is directly related to deterioration in dopaminergic neurotransmission in the corpus striatum, which is a brain region rich in dopamine receptor sites (54). The use of L-DOPA, the biosynthetic precursor of dopamine, in treatment of patients with Parkinson s disease is one of the best examples of biochemically directed medical treatment. [Pg.138]

The etiology of progressive death of dopaminergic neurons in substantia nigra of Parkinson s disease brains remains unclear. Dopamine deficiency in Parkinson s disease is commonly treated with L-dopa and carbidopa, a periphera dopa decarboxylase inhibitor (Sinemet). Since its introduction, L-dopa has been shown to be effective in treating Parkinson s disease. However, high concentrations of L-dopa produce side effects such as psychosis, on-off effects, abnormal involuntary movements, and akinetic crisis. [Pg.191]

Tanner CM (1989) The role of environmental toxins in the etiology of Parkinson s disease. Trends Neurosci 72 49-54. [Pg.298]

Verhoeven WMA, Tuinier S (1993) Dopaminometic psychosis Thoughts on etiology. In Wolters ECh, Scheltens P (Eds), Mental Dysfunction in Parkinson s Disease, ICG Printing, Dordrecht. [Pg.433]


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See also in sourсe #XX -- [ Pg.248 ]




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Etiology

Etiology of Parkinson Disease Genetic and Environmental Factors

Parkinson’s disease etiology

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