Parke-Davis company

Slack, R. U.S. Patent 2,7B6,B70 March 26, 1957 assigned to Parke, Davis Company... 

The pamphlets are to be edited by the following committee Roger Adams, University of Illinois, Urbana, Illinois J. B. Conant, Harvard University, Cambridge, Massachusetts H. T. Clarke, Eastman Kodak Company, Rochester, New York Oliver Kamm, Parke, Davis Company, Detroit, Michigan each to act for one year as editor-in-chief and the other three to assist him as associate editors. A new number of the series will appear annually, and every five years the data will be rearranged, revised, corrected, and then published in book form. The number of preparations to be completed yearly is not fixed. There will be, it is certain, about twenty and it is hoped, as the interest is stimulated in this work, that this number may increase considerably. The editors especially desire to solicit contributions from other chemists, not only in this country but abroad. Whenever a compound is thoroughly and extensively studied in connection with some research, it is hoped that... 

Research Laboratories, Parke, Davis Company, Ann Arbor, Michigan. 

From the Parke. Davis Company 1929-1930 physicians catalog... 

Although any of the foregoing methods could, in principle, have been applied to the synthesis of substituted 2,1-benzisothiazoles, no such attempt was made and until 1963 the parent compound (2) was the sole representative of this heterocyclic system. In that year a group from the Parke, Davis Company filed a patent application100 in which the preparation of a number of 3-substituted 2,1-benzisothiazoles was described. This application, shortly followed by a definitive paper,101 indicated how o-aminothiobenzamides (69) could be oxidized, and o-nitrothiobenzamides (70) reduced, with concomitant ring closure to yield 3-amino-2,l-benzisothiazoles (71). 

Parke, Davis Company, Netherlands Patent Application 6,408,290 Chem. Abstr. 63, 1768 (1965). 

The search by the Parke-Davis company for drugs to treat strokes provided an interesting application of dienophile stereochemistry. The kinds of compound they wanted were tricylic amines. They don t look like Diels-Alder products at all. But if we insert a double bond in the right place in the six-membered ring, Diels-Alder (D-A) disconnection becomes possible. 

The reactions outlined in the chart below describe the early steps in a synthesis of an antiviral drug by the Parke-Davis company. 

Bender, G.A. Great Moments in Pharmacy The Stories and Paintings in the Series A History of Pharmacy in Pictures by Parke, Davis Company Northwood Institute Press Detroit, 1966. 

The reactions outlined in the chart below were the early stages in a synthesis of an antiviral drug by the Parke-Davis company. Consider how the reactivity of imidazoles is illustrated in these reactions, which involve not only the skeleton of the molecule but also the reagent D. You will need to draw mechanisms for the reactions and explain how they are influenced by the heterocycles. 

It is noted that the Parke Davis Company produced and sold a weaker vaccine from 1898 to 1962, which proved ineffective at ordinary dosages, but was effective at much greater dosages. The therapy continues at present on a limited basis using laboratory-made vaccines, with dramatic remissions in evidence, and overdoses can be monitored and controlled by a rectal suppository of Tylenol. It is concluded that, with larger dosages under Tylenol control, the results should be far better than in Coley s time. 

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