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Parathyrin

Calcium and phosphate ions. Calcium (Ca " ) and phosphate ions are almost completely resorbed from the primary urine by active transport (i.e., in an ATP-dependent fashion). The proportion of Ca "" resorbed is over 99%, while for phosphate the figure is 80-90%. The extent to which these two electrolytes are resorbed is regulated by the three hormones parathyrin, calcitonin, and calci-triol. [Pg.328]

The peptide hormone parathyrin (PTH), which is produced by the parathyroid gland, stimulates Ca "" resorption in the kidneys and at the same time inhibits the resorption of phosphate. In conjunction with the effects of this hormone in the bones and intestines (see p. 344), this leads to an increase in the plasma level of Ca and a reduction in the level of phosphate ions. [Pg.328]

Calcitonin, a peptide produced in the C cells of the thyroid gland, inhibits the resorption of both calcium and phosphate ions. The result is an overall reduction in the plasma level of both ions. Calcitonin is thus a parathyrin antagonist relative to Ca ". ... [Pg.328]

Calcitriol (vitamin D hormone, lo,25-dihy-droxycholecalciferol) is a hormone closely related to the steroids that is involved in Ca homeostasis (see p. 342). In the kidney, it is formed from calcidiol by hydroxylation at C-1. The activity of calcidiol-1-monooxygenase [1] is enhanced by the hormone parathyrin (PTH). [Pg.330]

Parathyrin (parathyroid hormone, parathormone, PTH) is secreted by the parathyroid glands. A peptide of 84 amino acids, it has two precursors during its biosynthesis, a... [Pg.363]

Potts JT, Jr., Bringhurst FR, Gardella TJ, et al. Parathyroid hormone Physiology, chemistry, biosynthesis, secretion, metabolism, and mode of action. In Degroot LJ (Ed.), Endocrinology. W.B. Saunders, Philadelphia, PA (1996) 920-965. Nussbaum SR, Zahradnik RJ, Lavigne JR, et al. Highly sensitive two-site immuno-radiometric assay of parathyrin and its clinical utility in evaluation patients with hypercalcemia. Clin. Chem. (1987) 33 1364-1367. [Pg.179]

Dispersion of physiological concentrations of parathyrine in blood serum influence diurnal rhythm, hourly pulsation, oral load with calcium, exercise, pregnancy, age, and menstrual cycle. There are no sex differences. Medication, resection of a tumor causing hypercalcemia, hypertension, and urolithiasis are the causes of pathophysiological mechanisms that also influence the blood level of parathyrine. Establishing the intact PTH provides sufficient reliability and comparability of the results provided the preanalytic phase is maintained. [Pg.268]

Juppner H, Mohr H, Hesch RD. Adsorption of parathyrin Pitfall for solid phase assays using radio-labelled antibodies J Chn Chem Clin Biochem 1980 18 585-90. [Pg.525]

Armitage EK. Parathyrin (parathyroid hormone) metabolism and methods of assay. Clin Chem 1986 32 418-24. [Pg.1944]

Blind E, Schmidt-Gayk H, Armbruster FP, Stadler A. Measurement of intact human parathyrin by an extracting two-site immunoradiometric assay, Clin Chem 1987 33 1376-81. [Pg.1945]

Bohler U, Bind E, Vogel G, Hitzler W, Flentje D, Schmidt-Gayk H. Two-site immunochenulumino-metric assay of intact human parathyrin in serum with use of a tracer peptide purified by reversed-phase high-performance liquid chromatography. [Pg.1945]

Bouillon R, Coopmans W, Degroote DEH, Radoux D, Eliard PH. Immunoradiometric assay of parathyrin with polyclonal and monoclonal region-specific antibodies. Clin Chem 1990 36 271-6. [Pg.1946]

Boyd JC, Lewis JW, Siatopoksky E, Ladenson JH. Parathyrin measured concurrently with free and total calcium in the differential diagnosis of hypercalcemia. Clin Chem 1981 27 574-9. [Pg.1946]

DEena BA, White GH. Interference with the measurement of intact parathyrin in serum from renal dialysis patients. Clin Chem 1989 35 1543-4. [Pg.1949]

DEena BA, White GH. Assessing acute parathyroid responsiveness in hemodialysis patients by measuring intact parathyrin in pre- and post-dialysis serum. [Pg.1949]

Endres DB. Which parathyrin assay is reaEy best for clinical use Clin Chem 1991 37 1466-7. [Pg.1949]

Endres DB, Villanueva R, Sharp CF Jr, Singer FR, ImmunochemEuminometric and immunoradiomet-ric determinations of mtact and total immunoreactive parathyrin performance in the differential diagnosis of hypercalcemia and hypoparathyroidism. CEn Chem 1991 37 162-8. [Pg.1949]

Klee GG, Preissner CM, Schryver PG, Taylor RL, Kao PC. Multisite immunochemiluminometric assay for simultaneously measuring whole-molecule and amino-terminal fragments of human parathyrin. Clin Chem 1992 38 628-35. [Pg.1954]

Lepage R, Whittom S, Bertrand S, Bahsali G, D Amour P. Superiority of dynamic over static reference intervals for intact, mid-molecule, and C-termi-nal parathyrin in evaluating calcemic disorders. Clin Chem 1992 38 2129-35. [Pg.1955]

Nussbaum SR. Immunometric assays of parathyrin in the diagnosis of hypercalcemic individuals. Clin Chem 1991 37 142-3. [Pg.1958]

Nussbaum SR, Zahradrik RJ, Lavigne JR, Brennan GL, Nozawa-Ung K, Kim LY. Highly sensitive two-site immunoradiometric assay of parathyrin, and its clinical utility in evaluating patients witli hypercalcemia. Clin Chem 1987 33 1364-7. [Pg.1958]

Ratcliffe WA, Heath DA, Ryan M, Jones SR. Performance and diagnostic application of a two-site immunoradiometric assay for parathyrin in serum. Clin Chem 1989 35 1957-61. [Pg.1959]

Ratchffe WA, Norbury S, Heath DA, Ratcliffe JG. Development and validation of an immunoradiometric assay of parathyrin-related protein in unextracted plasma. Clin Chem 1991 37 678-85. [Pg.1959]

Saggese G, BaronceUi GI, Bertelloni S. Determination of intact parathyrin by immunoradiometric assay evaluated in normal children and in patients with various disorders of calcium metabolism. Clin Chem 1991 37 1999-2001. [Pg.1961]

Kll. Klee, G. G., Preissner, C. M., Schryver, P. G., Taylor, R. L., and Kao, P. C., Multisite immunochemiluminometric assay for simultaneously measuring whole-molecule and Amino-Terminal fragments of human parathyrin. Clin. Chem. (Winston-Salem, N.C.) 38, 628-635... [Pg.169]

Parathyroid hormone (PTH), parathormone, parathyrin, SVSEIQLMHN LGKHLNS MER VEWLRKKLQD VHNFVALGAP ... [Pg.259]

See other pages where Parathyrin is mentioned: [Pg.331]    [Pg.364]    [Pg.363]    [Pg.1744]    [Pg.1750]    [Pg.255]    [Pg.267]    [Pg.79]    [Pg.228]    [Pg.214]    [Pg.1021]    [Pg.134]    [Pg.831]    [Pg.837]    [Pg.335]    [Pg.810]    [Pg.816]    [Pg.600]   
See also in sourсe #XX -- [ Pg.311 , Pg.360 , Pg.363 ]

See also in sourсe #XX -- [ Pg.21 , Pg.422 ]



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