Paracetamol Chloroquine

Magnesium oxide is a basic compound and as such can react with acidic compounds in the solid state to form salts such as Mg(ibuprofen)2 or degrade alkaline-labile drugs. Adsorption of various drugs onto magnesium oxide has been reported, such as antihistamines, antibiotics (especially tetracyclines), salicylates, atropine sulfate, hyoscyamine hydrobromide, paracetamol, chloroquine, and anthranilic acid derivatives have been reported to adsorb onto the surface of magnesium... 

Increased bilirubin levels are caused due to the intake of large doses of such drugs as chloroquine, vitamin K, sulpha-drugs, tetracyclines, paracetamol, nicotinic acid and monoamine oxidase inhibitors (e.g., iproniazid RP 1.0 nialamide RP 1.8 isocarboxazid RP 3.1 phenelzine RP 18 pheniprazine RP31 and tranylcypromine RP 45), where RP designates the Relative Potency based on the tiyptamine potentiation test. The elevated levels are due to hepatic injury, and... 

Iwuagwu MA, Aloko KS. Adsorption of paracetamol and chloroquine phosphate by some antacids. / Pharm Pharmacol 1992 44 655-658. 

Magnesium silicate may decrease the oral bioavailability of drugs such as mebeverine hydrochloride, sucralfate, and tetracycline, via chelation or binding, when they are taken together. The dissolution rate of folic acid, erythromycin stearate, paracetamol, " and chloroquine phosphate, " may be retarded by adsorption onto magnesium silicate. Antimicrobial preservatives, such as parabens, may be inactivated by the addition of magnesium silicate. ... 

Although modest pharmacokinetic effects occur when paracetamol and chloroquine are given together this is not thought to be clinically significant. 

Adjepon-YamoahKK, WoolhouseNM,PrescottLF. The effect of chloroquine on paracetamol disposition and kinetics. BrJ Clin Pharmacol ( 9Z6) 21,322—4. 

Raina RK, Bano G, Amla V, Kapoor V, Gupta KL. The effect of aspirin, paracetamol and analgin on pharmacokinetics of chloroquine. Indian J Physiol Pharmacol (1993) 37,229-31. 

EssienEE, Ette El, Brown-Awala EA. Evaluation oftiie effect of co-administered paracetamol on tile gastro-intestinal absorption and disposition of chloroquine. J Pharm Biomed Anal (1988) 6, 521-6. 

Musa paradisiaca starch Binder Paracetamol and chloroquine [6]... 

Ensete ventricosum starch Binder and disintegrant Paracetamol and chloroquine [7]... 

Iwuagwu, M.A., and Aloko, K.S., 1992, Adsorption of Paracetamol and Chloroquine Phosphate by Some Antacids , Journal of Pharmaceutical and Pharmacological... 

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