Mebeverine hydrochloride

Foda NH. Compatibility study between Fluvoxamine Maleate, mebeverine hydrochloride and tablet excipients using differential scanning calorimetry. Egypt J Pharm Sci 1992 33(1—2) 73—81. 

Loxapine Succinate 466.0 Mebeverine Hydrochloride 491.1 Verapamil Hydrochloride... 

Mebeverine Hydrochloride 140-142 Isoniazid Aminosalicylate 147-152d Adrenaline Acid Tartrate ... 

The effectiveness and safety of two formnlations of mebeverine hydrochloride (200 mg capsules bd and 135 mg tablets tds) in 213 patients with irritable bowel syndrome have been studied in a randomized, doubleblind, general practice study lasting 8 weeks (1). The two formulations were equally effective in relieving abdominal pain. The frequencies of reported adverse events were similar in the two groups and were considered unlikely to be related to the medication. 

Magnesium silicate may decrease the oral bioavailability of drugs such as mebeverine hydrochloride, sucralfate, and tetracycline, via chelation or binding, when they are taken together. The dissolution rate of folic acid, erythromycin stearate, paracetamol, " and chloroquine phosphate, " may be retarded by adsorption onto magnesium silicate. Antimicrobial preservatives, such as parabens, may be inactivated by the addition of magnesium silicate. ... 

Al-Gohary OMN. An in vitro study of the interaction between mebeverine hydrochloride and magnesium trisilicate powder. Int J Pharm 1991 67 89-95. 

Mebeverine hydrochloride is a musculotropic antispasmodic claimed to act directly on the smooth muscle of the intestine without affecting normal gut motility. 

Clidinium bromide, another quaternary ammonium compound with antimuscarinic activity, is used in a fixed combination with chlordiazepoxide hydrochloride (2.5 mg of clidinium and 5 mg of chlordiazepoxide Librax) however, such combinations are of limited value in patients with IBS because of the risk of habituation and rebound withdrawal. Cimetropium is another antimuscarinic compound that reportedly is effective in patients with IBS. Otilonium bromide has been used extensively for patients with IBS in other parts of the world. It is an ammonium salt with antimuscarinic effects that also appears to block Ca + channels and neurokinin NK-2 receptors. Mebeverine hydrochloride is a derivative of hydroxybenzamide that appears to have a direct effect on the smooth-muscle cell, blocking K+ and Ca channels. It is widely used outside of the United States as an antispasmodic agent for patients with IBS. 

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