Parabens allergic reactions

Wherever possible I aim to incorporate Myavert C, which has one of the lowest irritation potentials in combination with parabens or potassium sorbate. This combination has reduced the customer complaints from a low to negligible level in all face products in which this combination is used by a skin-care marketing company. Typically the complaints for allergic reaction is in the range of one in 200,000 to 1,000,000 packs sold for face products suitable for all skin types. However, there are... 

General allergic reactions have also been reported following injections of parabens-containing formulations of lido-caine and hydrocortisone and after oral use of barium sulfate contrast suspension, haloperidol syrup, and an antitussive syrup, all of which contained parabens (44). 

Complications noted at various times with submucosal use include allergic reactions to the parabens present in lidocaine, systemic effects due to general diffusion (which... 

Parabens (methyl, ethyl, propyl, and butyl esters of para-hydroxybenzoic acid) are used as preservatives in concentrations of 0.1-0.3% in pharmaceutical formulations and in concentrations of 0.01-0.1% in cosmetics and foods. In such concentrations they are devoid of systemic toxic effects, but allergic reactions have been reported. 

Parabens (including methyl-, ethyl-, propyl-, and butylparaben) are used widely in pharmaceutical products as a biocidal agent. The majority of allergic reactions to parabens are observed after topical exposure. Delayed hypersensitivity contact dermatitis occurs more often in individuals with preexisting dermatitis. Immediate hypersensitivity after parenteral administration is rare. Although these... 

Preservatives Parabens (methylparaben, ethylparaben, butylparaben, propylparaben, etc.), EDTA, Formaldehyde, Quaternium 15, Methylisothiazolinone Skin irritation and allergic reactions. Can be neurotoxic. Some, like parabens, are suspected hormone disrupters. Also found in all cosmetics and toiletries. 

Preservatives such as parabens, i.e., esters ofp-hydroxybenzoic acid are used in the pharmaceutical and cosmetic industry as well as in foods. Allergic reactions to parabens have been reported with increasing frequency from the United States (Fischer 1973). Contact allergy to sorbic acid has also been reported but seems to be rare (Hjort and Trolle-Lassen 1962 Klaschka and Beiersdorff 1965 Fischer et al. 1971 Sadhan and Harman 1978 Brown 1979). That the dermatitis should flare up or get worse after intravenous or oral ingestion of such preservatives has not been reported. 

Landon J, Wynn V, Wood JB (1965) Adrenal response to infused corticotropin in subjects receiving glucocorticoids. J Clin Endocrinol 25 602 Mendelson LM, Meltzer EO, Hamburger RN (1974) Anaphylaxis like reactions to corticosteroid therapy. J Allergy Clin Immunol 54 125 Mohr PD (1975) Allergic reactions to tetracosactrin. Br Med J 4 162 Nagel JF, Fuscaldo JT, Fireman P (1977) Paraben allergy. JAMA 237 1594... 

Diazolidinylurea (Germall II). This is used widely as a preservative in liquid soaps, and is often combined with parabens (or other antifungal formulations). Allergic reactions occur - especially when stay-on products are used. Cross-reactions to and from imidazolidinyl urea occur (Ford and Beck 1986). Patch-test concentrations are 2% aqua or 2% pet. Allergic reactions are uncommon. 

Chloroacetamide (CAS no. 79-07-2). This is a well-known cosmetic biocide, but sensitization is less common than with parabens. An allergic reaction was reported to deodorant (Taran and Delaney 1997) The patch-test concentration is 0.2% pet. Allergic reactions do occur. 

Patients with known allergic reactions to methyl-paraben or propylparaben may develop allergic reactions to the lidoderm patch. Severe hypersensitivity-types of reactions to lidoderm are rare. 

The literature is replete with reports of various allergic-type reactions to preservatives (parabens, chlorocresol), antioxidants (propyl gallate, metabisulphite), surfactants and solvents. The list is too long to be discussed in this article but Ref. contains a... 

---