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Palythoa tuberculosa

Two isomeric compounds possessing a pyrazine ring system, palythazine (31), and isopalythazine (32), have been obtained from this zoanthid, which is native to Japan.32 [Pg.244]


Materials. I-EGF was either made by iodinating mouse EGF (Biomedical Technologies Inc.) by the chloramine T method, to a specific activity of approximately 1-2 Ci/ xmol, using Na- I (Amersham) or purchased from New England Nuclear. Phorbol diterpene esters were purchased from Sigma. Palytoxin was isolated from Palythoa tuberculosa as previously described (1). [Pg.206]

This work was supported by Grant GM 27256 from the National Institutes of Health and Grant DA 02507 from the National Institute of Drug Abuse. LL. is an American Cancer Society Research Professor of Biochemistry (Award PRP-21). H.V.V. is the recipient of a Research Career Award (5K6-AI-2372) from the National Institute of Allergy and Infectious Disease. We thank Dr. Y. Hirata of Meijo University for generous gifts of palytoxin isolated from Palythoa tuberculosa. We thank Dr. T. Yasumoto, Tohoku University, Sendai, Japan, for the maitotoxin preparation. We thank also Jeffrey A. Bessette and Nancy Worth for their technical assistance and Inez Zimmerman for preparation of the manuscript. [Pg.231]

Hirata, Y., Uemura, D., Ueda, K., and Takano, S., Several compounds from Palythoa tuberculosa (Colenterata), Pure Appl. Chem., 51, 1875, 1979. [Pg.514]

Ito, S. and Hirata, S., Isolation and structure of a mycosporine from the zoanthid Palythoa tuberculosa, Tetrahedron Lett., 1977, 2429, 1977. [Pg.514]

The versatility of the enolone ester 27 is illustrated by a variety of synthetically useful addition reactions, e. g. with lithium alkyls, Grignard reagents and cyclopentadiene in a Diels-Alder type fashion (40, 48, 49), but, most notably, it could be utilized for straightforward syntheses of the marine natural products (-)-bissetone (28), a metabolite from the Gorgonian soft coral Briareum polyanthes (50), and (-)-palythazine (29), an unusual dipyranopyrazine isolated from the salt water invertebrate Palythoa tuberculosa (51). [Pg.61]

Figure 5.4. Ultraviolet spectrum of reference palytoxin from Palythoa tuberculosa at 25 pg/ml in water. Figure 5.4. Ultraviolet spectrum of reference palytoxin from Palythoa tuberculosa at 25 pg/ml in water.
Hashimoto, Y., Fusetani, N., and Kimura, S. 1969. Aluterin a toxin of filefish, Alutera scripta, probably originating from a zoantharian Palythoa tuberculosa. Bulletin of the Japanese Society of Scientific Fisheries 35 1086-1093. [Pg.91]

Palytoxin has been isolated to date in numerous areas of the world both from zoanthids belonging to the genus Palythoa and in other species. Moore and Scheuer [3] first reported the isolation of palytoxin from the Hawaiian zoanthid Palythoa toxica, while 1 year later, it was also isolated from Palythoa tuberculosa in tropical Pacific waters of Okinawa, Japan [8]. Since then, palytoxin and its congeners have been found in P. vestitus from Hawaii [9], P. mammilosa [10] and P. caribaeorum... [Pg.632]

Kimura, S., Yamazato, K., and Hashimoto, Y., Studies on marines toxins 35. Toxicity of zoanthid Palythoa tuberculosa, Toxicon, 10, 611, 1972. [Pg.673]

Kudo, Y. and Shibata, S., The potent depolarizing action of palytoxin isolated from Palythoa tuberculosa on the isolated spinal-cord of the frog, Br. J. Pharmacol, 71, 575, 1980. [Pg.673]

Hirata, Y. and Uemura, D., [Toxic compounds of Palythoa tuberculosa (Coelenterata), palytoxin and its analogs], Yakugaku Zasshi 105, 1, 1985. [Pg.688]

Deguchi, T., Urakawa, N., and Takamatsu, S., Some pharmacological properties of palythoatoxin isolated from the zoanthid, Palythoa tuberculosa, in Animal, Plant and Microbial Toxins, Ohsaka A., Hayashi, K., and SawaiY. Eds., Plenum Press, New York, 2, 379, 1976. [Pg.713]

Kimura S. and Hashimoto Y, Purification of the toxin in a zoanthid Palythoa tuberculosa, Publ. Seto Marine Biol. Lab, 20, 713, 1973. [Pg.713]

Tetrodotoxin, from the puffer fish and other members of the order Tetraodontiformes, is a neurotoxin much like saxitoxin in its mechanism of action, toxicity, and physical characteristics. Palytoxin, from the soft coral Palythoa tuberculosa, is extremely toxic and quite stable in impure form, but difficulty of production or harvest from nature reduces the likelihood that an aggressor would use it as an MCBW. The brevetoxins, commonly associated with red tide dinoflagellate blooms, and the blue-green algal toxins like microcystin, a hepatotoxin, have limited toxicity. [Pg.609]

Paracentrotus lividus and Palythoa tuberculosa. Identified in the caprophores of Helvetia leucomelaneae and in extracts of Trichothecium roseum. Syrup. 268 nm (e 15700) (H ), 292 (25100) (OH ). [Pg.117]


See other pages where Palythoa tuberculosa is mentioned: [Pg.45]    [Pg.244]    [Pg.61]    [Pg.75]    [Pg.82]    [Pg.87]    [Pg.335]    [Pg.335]    [Pg.335]    [Pg.335]    [Pg.76]    [Pg.658]    [Pg.667]    [Pg.688]    [Pg.693]    [Pg.709]    [Pg.416]    [Pg.48]    [Pg.137]   
See also in sourсe #XX -- [ Pg.75 , Pg.82 , Pg.87 ]

See also in sourсe #XX -- [ Pg.5 , Pg.390 , Pg.391 , Pg.393 ]

See also in sourсe #XX -- [ Pg.5 , Pg.390 , Pg.391 , Pg.393 ]

See also in sourсe #XX -- [ Pg.609 ]

See also in sourсe #XX -- [ Pg.491 ]

See also in sourсe #XX -- [ Pg.213 ]




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