P-Methyl Anisole, 524,

The direct coupling of the tin enolate (175 Scheme 25) with (30) gives complex (176) in good yield (87%). Fortuitously, the bond formation gives approximately a 5 1 mixture in favor of the diastereomer required for trichothecene synthesis. Further elaboration of the major isomer leads to (i)-trichodiene (167), representing an eight step diastereoselective total synthesis of the natural product from p-methyl-anisole, which compares very favorably with previous methods.32-36... 

METHYL-o-ANISIDINE see MGO750 p-METHYL ANISOLE see MGPOOO 9-METHYLANTHRACENE see MGP750 METHYL ANTHRANILATE (FCQ see APJ250 N-METHYLANTHRANILIC ACID, METHYL ESTER see MGQ250... 

Problem 17.13 Predict the principal products of (a) bromination of p-methyl-anisole (b) nitration of m-nitroanisole (c) nitration ol benzyl phenyl ether. 

PADS ODAN mole% Tg (°C) Thermostability (°C) NMP p-methyl anisole chloroform... 

Fora (4-Methyl anisole, p-Cresyl methyl ether, p-Methoxy toluene or Methyl-p-Cresol), colorl... 

Mononitro Methyl Anisole (2-Nitro-4-methyl anisole, 3-Nitro4-methoxy l-methyl benzol or Methyl- [2-nitro4 methyl phenyl]-ether). CH3.0.(N02)C6H3.CH3, mw 167.18, N 8.38%, OB to C02-167.48%, pale yellow cryst, mp 8.5°, bp 274° (partial decompn), d 1.2025 g/cc at 25/4°, Rl 1.5536 si sol in eth (Ref 1). Prepd by heating K2-nitro-p-cresol with methyl-iodide methylalc in a sealed tube at 100°... 

C7H7)+ Various including toluene, butylbenzene, benzyl chloride, xylene, benzyl alcohol, methyl anisole 29—46 g, m, P 185... 

Finally, 2,4,6-tricyanophenol m.p. 185° has been prepared from 2,4,6-tris-carboxy-methyl-anisol by an analogous route. It is a strong acid (pk 1.0) which can only be prepared from the pyridinium salt to give the phenol by cation exchange with lewatit S 140147 >. 

Methyl anisole [104-93-8] M 122.2, b 56.2 /9mm, 67 /20mm, 175-176 /760mm, d f 0.9757, ng 1.512. Dissolve 4-methyl anisole in diethyl ether, wash it with M NaOH, water, diy (Na2C03), evaporate and distil it under vacuum. The p/crate has m 103 (from aqueous EtOH). [Beilstein 6 IV 2098.]... 

In / . methyl anisole. the para position at which trifluoroacetylation occurs in anisole is now blocked by the methyl substituent. With 5 equivalents of TFA, we have obtained the product resulting from the exclusive regiospecific trifluoroacetylation in ortho position with respect to the methoxy group without formation of a dimer (eqn. 10). The yield is lower than in the case of anisole, however, if the reaction time is only 15 h. at 100°C and unreacted p.methylanisole can be recovered. 

AI3-07621 Anisole, p-methyl- Benzene, 1-methoxy-4-methyl- EINECS 203-253-7 FEMA Number 2681 HSDB 5363 Methyl 4-methylphenyl ether Methyl p-cresol Methyl p-cresyl ether Methyl p-methylphenyl ether Methyl p-tolyl ether Methyl-para-cresol NSC 6254 Toluene, 4-methoxy-. Oil mp = -32° bp = 175.5° = 0,969 ... 

Anisole, p-methoxy-. See p-Dimethoxybenzene Anisole, o-methyl-. See o-Methylanisole Anisole, o-nitro-. See o-Nitroanisole Anisole, o-phenyl-. See o-Phenyl anisole Anisole, p-propenyl-, (E) Anisole, p-propenyl-, trans-. See trans-Anethole Anisomycin... 

Propyl methoxybenzene. See p-Propyl anisole 1 -Propyl-3-methoxy-4-hydroxybenzene 4-Propyl-2-methoxyphenol. See Dihydroeugenol Propyl-2-methyl butyrate CAS 37064-20-3 Properties Flash pt. (CC) 42 C Uses Fragrance flavor... 

Copper-iron-polyphthalocyanine [251,252] showed a specific catalysis for the oxidations of saturated aldehydes and substituted benzaldehydes with oxygen. The catalytic reaction was solvent dependent so that tetrahydrofuran, ethanol, acetonitrile, ethyl acetate and anisole inhibited benzaldehyde oxidation while oxidation occurred readily in benzene or acetone. Benzaldehyde was catalytically oxidized with copper-iron-polyphthalocyanine and oxygen to give a quantitative yield of a mixture of perbenzoic (61%) and benzoic (39%) acids. Reaction was carried out at 30 °C and atmospheric pressure of oxygen and exhibited no induction period. By contrast p-methyl and p-chlorobenzaldehyde had induction periods of 8 and 15 min respectively while no oxidation of p-substituted benzaldehydes was observed when the para-substituent was NO2, OH, OCH3, or N(CH3)2. 

---