P2 adrenergic receptor

Zhong, H., Guerrero, S. W., Esbenshade, T. A., and Minneman, K. P. (1996). Inducible expression of 3 - and P2-adrenergic receptors in rat C6 glioma cells Functional interactions between closely related subtypes. Mol. Pharmacol. 50 175-184. 

Ritodrine has an effect on beta (p)2-adrenergic receptors, principally those that innervate the uterus. Stimulation of these p2-adrenergic receptors inhibits uterine smooth muscle contractions. The pradrenergic receptors are located in the heart and are not stimulated by ritodrine when administered as prescribed. Ritodrine is used to... 

Corticosteroids are the most potent anti-inflammatory agents available for the treatment of asthma. The efficacy of corticosteroids is due to their ability to affect multiple inflammatory pathways, resulting in the suppression of inflammatory cell activation and function, prevention of microvascular leakage, decreased mucus production, and upregulation of P2-adrenergic receptors.10,18 Clinically, corticosteroids decrease airway inflammation, decrease AHR, decrease mucus production and secretion, and improve the response to P2-agonists.18 Corticosteroids for the treatment of asthma are available in inhaled, oral, and injectable dosage forms. 

Samama, P., Cotecchia, S., Costa, T., and Lefkowitz, R. J., A mutation-induced activated state of the p2-adrenergic receptor extending the ternary complex model, J. Biol. Chem., 268, 4625-4636, 1993. Stephenson, R. P., A modification of receptor theory, Br. J. Pharmacol., 11, 379-393, 1956. 

Some failures will be due to the presence of variants in drug handling. Patients who are rapid acetylators of isoniazid have a slower antituberculous response than slow acetylators (Evans and Clarke, 1961). Asthmatics who do not respond well to (32-agonist bronchodilators may have fewer functioning p2-adrenergic receptors (Drysdale et al., 2000). Variations in the synthesis or structure of the serotonin transporter protein, which is involved in selective reuptake of serotonin by presynaptic neurons, may explain why some patients with depressive disorders respond to selective serotonin reuptake inhibitors and others do not (Steimer et al., 2001). 

Gkoutos, G. V., Higgs, C., Bywater, R. P Gouldson, P. R., and Reynolds, C. A. (1999) Evidence for dimerization in the p2-adrenergic receptor from the evolutionary trace method. Inti. J. Quantum. Chem. Biophys. Q. 74,371-379. 

Benovic J Novel p2-adrenergic receptor signaling pathways. J Allergy Clin Immunol 2002 10 S229-S235. 

P2-adrenergic receptors may function similar to HR2 in humans [196,197]. The role of histamine and other redundant G-protein-coupled receptors in the regulation of inunune/inflammatory pathways in allergic inflammation remain to be intensely focused in future studies. 

Fig. 8.5 A comparison of A3AR models based on bovine rhodopsin, the human P2-adrenergic receptor, and the A AR as templates. On the left Extracellular side view of hAjAR models based on different templates and estimated volume of the binding pockets. On the right Representation of EL2 of each hAjAR model (in yellow hA3AR built from rhodopsin, in magenta hA.AR built from 32-AR and in cyan hA3AR built from hA AR)...

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