Oxopropionic acid

Oxopropionic acid 2-Oxo-l -pyrrolidine-propionitrile CH3C(=0)C02H 88.06 138.17 3, 608... 

The 3-oxopropionic acid ethyl ester can be made to react with CF3SCI by way of metallation mono- and disubstituted products are formed in this reaction in equal amoimts (49) ... 

Pyruvic acid (= 2-Oxopropionic acid) Universal Panax quinquefolius (Araliaceae), Allium cepa (Liliaceae) Sour (acid) taste... 

From 3-oxopropionic acid arylidenehydrazides. Irradiation of 3-oxo-3-(4-oxo-l,4-dihydro[l,8]naphthyridin-3-yl)propionic acid arylidenehydrazides 226a-f over acidic alumina for 1-5 min afforded the corresponding pyrazol-3-ones 227a-f in excellent yields (02IJC(B)427) (Scheme 51). 

The reactions of /f-mercaptoethylamine, L-cysteine, and D-penicillamine, and their derivatives, with a-haloketones represent an important synthetic route to dihydrothiazines.44-46,52-54 For example, the methyl esters of L-cysteine and D-penicillamine reacted with 3-bromo-2-oxopropionic acid... 

Beilstein Handbook Reference) Acetylformic acid AI3-11220 BRN 0506211 BTS EINECS 204-824-3 FEMA No. 2970 a-Ketopiopionic acid 2-Ketopropionic acid NSC 179 2-Oxopropanoic acid, 2-Oxopropionic acid Propanoic acid, 2-oxo- Pyroracemic acid Pyruvic acid. Chemical intermediate and used in biochemical research. Liquid mp = 13.8° bp = 165° (dec), bpio = 54° d = 1.2272 Xm = 285m nm (c = 8, H2O) soluble in MezCO, freely soluble in H2O, EtOH, Et20. Lancaster Synthesis Co., Penta Mfg. U.S. BioChem. 

It is also of interest to note that the GRE-activating enzymes are not the only radical SAM proteins that act on a protein substrate AtsB catalyzes the formation of a Cct-formylglycine (2-amino-3-oxopropionic acid, FGly) on AtsA, thereby activating this arylsulfatase (see Section 8.17.3.8). 

N-C-C-C-N-N (c). 3-Diazo-2-oxopropionic acid derivatives 248a-d have been cyclized under a variety of conditions to 2,3>4,5 tetrahydro-l,2,3 triazine, 5 diones 41a-d (Equation 106). 

The C-C-C-N-N-N mode b of cyclization is represented by the cyclization of l-aryl-3-alkyl- (or aryl-) (3-hydro-xypropyO-triazenes giving 3,4,5,6-tetrahydro-l,2,3-triazinium salts 31 (Equation (103), Section 9.01.9) and by the preparation of l-alkyl-l,4,5,6-tetrahydro-l,2,3-triazines 30 (Equation 104). There is flexibility in the choice of substituents (alkyl, aryl). Highly functionalized 2,3,4,5-tetrahydro-l,2,3-triazin-4,5-diones (CA 2,3-dihydro-l,2,3-triazine-4,5-diones) 41 are available from the cyclization of 3-diazo-2-oxopropionic acid derivatives, but variation seems to be limited to the choice of the N-3 substituent (Equation 106). 

A metabolism study was conducted in male Wistar rats to determine the fate of the salt of 3-mercapto-2-oxopropionic acid, the intermediate product in the transamination pathway of L-cysteine metabolism. Results showed that the salt of 3-mercapto-2-oxopropionic acid is metabolized by reduction and frans-sulfuration to yield 3-mercaptolactate cysteine mixed disulfide (S-(2-hydroxy-2-carboxyethylthio) cysteine) and inorganic sulfate, respectively. The reduction is catalysed by lactate dehydrogenase, as indicated by the use of anti-lactate dehydrogenase antiserum. 

The reaction of pyruvic acid (2-oxopropionic acid) with PH3 in diethyl ether in the presence of dry HCl proceeds in two steps. First, the three P-H bonds each add to a keto group. Then, condensation leads to the formation of the tricyclic compound ((0)C0(CH3)C)3P in which the P atom functions as one of the bridgeheads [145]. 

Synonyms Acetylformic acid 2-Ketopropionic acid o-Ketopropionic acid 2-Oxopropanoic acid 2-Oxopropionic acid Propanoic acid, 2-oxo- Pyroracemic acid... 

Valine 2-Methylpropanal Aspartic acid 3-Oxopropionic acid... 

In some cases, Strecker aldehydes are unstable and decompose to other products. For example, aspartic acid produces 3-oxopropionic acid (2-129), which provides acetaldehyde by decarboxylation. Other products are pyruvic acid and fumaric acid. Glutamic acid produces 4-oxobutyric acid (4-oxobutanoic... 

Mamedov VA, Nuretdinov lA, Sibgatullina FG (1989) Reaction of 3-phenyl-3-chloro-2-oxopropionic acid derivatives with oriho-phenylenediamine. Bull Rus Acad Sci Div Chem Sci 38(6) 1292-1294. doi 10.1007/BF00957177 Mamedov VA, Kalinin AA, Gubaidullin AT, Litvinov lA, Levin YA (2002a) The Kornblum reaction of a-substituted 3-benzyl-l,2-dihydro-2-oxoquinoxalines. Synthesis and structure of 3-benzoyl-2-oxo-l,2-dihydroquinoxaline. Chem Heterocycl Compd 38(12) 1504-1510. doi 10.1023/A 1022601829731... 

---