Oxidative Stress and Interference with the Cytotoxic Effects of Antineoplastic Agents

OXIDATIVE STRESS AND INTERFERENCE WITH THE CYTOTOXIC EFFECTS OF ANTINEOPLASTIC AGENTS 

Nonradical oxygen species Hydrogen peroxide H202 

The cell cycle consists of a presynthetic phase (Gj), which precedes DNA synthesis, the phase of DNA synthesis (S), an interval that follows DNA synthesis (G2), and mitosis (M), during which the G2 cell with a double complement of DNA divides into two daughter cells. Each of these daughter cells may then immediately reenter the division cycle at Gj or pass into a nonproliferative state (G0) for an indefinite period of time. As the length of the cell cycle increases, the duration of the G phase increases, whereas the durations of the S, G2, and M phases remain relatively constant. 

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