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Oxidative reactions aryl hydroxylation

Oxidative Reactions. The majority of pesticides, or pesticide products, are susceptible to some form of attack by oxidative enzymes. For more persistent pesticides, oxidation is frequently the primary mode of metaboHsm, although there are important exceptions, eg, DDT. For less persistent pesticides, oxidation may play a relatively minor role, or be the first reaction ia a metaboHc pathway. Oxidation generally results ia degradation of the parent molecule. However, attack by certain oxidative enzymes (phenol oxidases) can result ia the condensation or polymerization of the parent molecules this phenomenon is referred to as oxidative coupling (16). Examples of some important oxidative reactions are ether cleavage, alkyl-hydroxylation, aryl-hydroxylation, AJ-dealkylation, and sulfoxidation. [Pg.215]

The exocyclic silyl dienes are useful for Diels-Alder reactions. The silyl group can also undergo Pd-catalyzed coupling with aryl iodides as well as oxidation to a hydroxyl group. [Pg.28]

Triphenylbismuth carbonate generally does not react with amines, although phenyl transfer to the amino functionality was first observed during an attempt of oxidation of the hydroxyl function of an aminoalcohol by triphenylbismuth carbonate in chloroform. It also reacted with iV-phenylhydro-xylamine under neutral or basic conditions to give diphenylnitroxyl and iV,iV-diphenylacetamide after reductive acetylation (29-33%). No reaction was noted between triphenylbismuth carbonate and nitrosobenzene. High-yielding -arylation was found in the reaction of amino-alcohols with triarylbismuth diacetate in methylene dichloride under reflux. 5... [Pg.178]

Both methods have been used to make adrenaline analogues. The broncho-dilator Metaproterenol (34) can be made from the a-keto aldehyde (3S) by familiar methods. Our new a-oxidation makes aryl ketone (36) a suitable starting material, though the hydroxyl groups will need protection during the oxidation.The strategy of a-oxidation appeals here because of the easy synthesis of ArCOMe by the Friedel-Crafts reaction. [Pg.198]

Molecular oxygen is used in a variety of oxidative detoxification reactions aromatic hydroxylation aryl oxidation O- and M-deaUcylation deamination and sulfoxidation. These reactions either modify functional groups or add oxygen to the foreign compound, forming metabolites that lack pharmacological activity and which are more rapidly eliminated in the urine because of increased water solubility. [Pg.464]

Under normal physiological conditions the bulk of L-phenylalanine is oxidatively metabolised by its initial transformation to L-tyrosine which is then oxidised to acetoacetate, fumarate and carbon dioxide Figure 4.1). The aryl hydroxylation reaction probably takes place in all higher animals and occurs in the liver . The same conversion... [Pg.129]

Beyer synthesis, 2, 474 electrolytic oxidation, 2, 325 7r-electron density calculations, 2, 316 1-electron reduction, 2, 282, 283 electrophilic halogenation, 2, 49 electrophilic substitution, 2, 49 Emmert reaction, 2, 276 food preservative, 1,411 free radical acylation, 2, 298 free radical alkylation, 2, 45, 295 free radical amidation, 2, 299 free radical arylation, 2, 295 Friedel-Crafts reactions, 2, 208 Friedlander synthesis, 2, 70, 443 fluorination, 2, 199 halogenation, 2, 40 hydrogenation, 2, 45, 284-285, 327 hydrogen-deuterium exchange, 2, 196, 286 hydroxylation, 2, 325 iodination, 2, 202, 320 ionization constants, 2, 172 IR spectra, 2, 18 lithiation, 2, 267... [Pg.831]

The proposed mechanism involves the usual oxidative addition of the aryl halide to the Pd(0) complex affording a Pd(II) intermediate (Ar-Pd-Hal), subsequent coordination of allene 8 and migratory insertion of the allene into the Pd-C bond to form the jt-allylpalladium(II) species 123. A remarkable C-C bond cleavage of 123 leads by decarbopalladation to 1,3-diene 120 and a-hydroxyalkylpalladium species 124. /8-H elimination of 124 affords aldehyde 121 and the H-Pd-Hal species, which delivers Pd(0) again by reaction with base (Scheme 14.29). The originally expected cyclization of intermediate 123 by employment of the internal nucleophilic hydroxyl group to form a pyran derivative 122 was observed in a single case only (Scheme 14.29). [Pg.867]

Chemical radicals—such as hydroxyl, peroxyhydroxyl, and various alkyl and aryl species—have either been observed in laboratory studies or have been postulated as photochemical reaction intermediates. Atmospheric photochemical reactions also result in the formation of finely divided suspended particles (secondary aerosols), which create atmospheric haze. Their chemical content is enriched with sulfates (from sulfur dioxide), nitrates (from nitrogen dioxide, nitric oxide, and peroxyacylnitrates), ammonium (from ammonia), chloride (from sea salt), water, and oxygenated, sulfiirated, and nitrated organic compounds (from chemical combination of ozone and oxygen with hydrocarbon, sulfur oxide, and nitrogen oxide fragments). ... [Pg.239]


See other pages where Oxidative reactions aryl hydroxylation is mentioned: [Pg.138]    [Pg.230]    [Pg.77]    [Pg.332]    [Pg.393]    [Pg.484]    [Pg.177]    [Pg.180]    [Pg.435]    [Pg.425]    [Pg.397]    [Pg.1182]    [Pg.122]    [Pg.405]    [Pg.832]    [Pg.835]    [Pg.149]    [Pg.151]    [Pg.297]    [Pg.74]    [Pg.47]    [Pg.299]    [Pg.238]    [Pg.264]    [Pg.164]    [Pg.257]    [Pg.1531]    [Pg.68]    [Pg.143]    [Pg.262]    [Pg.184]    [Pg.412]    [Pg.829]    [Pg.225]    [Pg.136]   
See also in sourсe #XX -- [ Pg.297 , Pg.298 , Pg.299 , Pg.300 ]




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Aryl hydroxylation

Arylic oxidation

Aryls oxides

Hydroxyl, reactions

Hydroxylation reaction

Oxidative arylation

Oxidative hydroxylation

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